Lack of detectable cross-neutralization
of HRTV by mouse hyperimmune ascites fluids containing high-titered antibodies to LSV, SCV, and RGV * Virus (challenge PRNT70 antibody titers dose, PFU) HRTV LSV SCV RGV HRTV (54) 160 <20 <20 <20 LSV (214) 20 >640 <20 <20 SCV (220) 20 <20 320 <20 RGV (14) <20 <20 <20 320 * HRTV, Heartland virus; LSV, lone star virus; [PRNT.
Studies shown that no antibody against ONN was produced eliminating the possibility of 2-way cross-neutralization
test between CHIK and ONN viruses (11,12).
Importantly, preliminary analysis of serum samples obtained from the study subjects suggests both the neutralization of the pandemic virus contained in the vaccine and cross-neutralization
against widely diverse strains of H5N1, including both Hongkong/156/97 and Indonesia/05/05.
Among volunteers who developed antibodies to the vaccine, cross-neutralization
results were similar in those who received high antigen (30microg) and those who received lower antigen (7.
Weiss told SCIENCE NEWS that this cross-neutralization
offers hope that broad-spectrum drugs may be effective against the changeable HIV-1 virus, which, like the influenza virus, is notorious for its rapid mutation rate (SN: 6/28/86, p.
We used established methods to obtain hyperimmune ascitic fluid for classic cross-neutralization
Neutralization assays confirmed the absence of cross-neutralization
between MERS-CoV and BCoV antibodies in either direction even at low dilutions, such as 1 AO.
Further studies, including extensive genomic sequence analyses and serologic cross-neutralization
tests, should be conducted.
Detection of extensive cross-neutralization
between pandemic and seasonal A/H1N1 influenza viruses using a pseudotype neutralization assay.
Some are likely to be attributable to cross-neutralization
, although co-infection cannot be ruled out because the results showed co-circulation of >1 flavivirus in game birds in most locations studied.
Of note, in the earlier PNG studies, titers against Hendra and Nipah viruses were modest (median 10) and pose the possibility of cross-neutralization
by a related, but undescribed, additional henipavirus.
This finding is noteworthy because our previous data indicated a one-way cross-neutralization
, with MenPV antibodies failing to neutralize TioPV (G.