cryoglobulin


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Related to cryoglobulin: cryofibrinogen, Cryoglobulin Test, cryoglobulinemia

cryoglobulin

[¦krī·ō′gläb·yə·lən]
(pathology)
An abnormal protein, usually an immunoglobulin, which precipitates from plasma between 40 and 70°F (4.4 and 21°C).
References in periodicals archive ?
Two pathophysiological mechanisms are mainly involved in the development of various degrees of CV: 1) cryoglobulin precipitation in the microcirculation, causing vascular occlusion, and 2) immune complex-mediated deposition within blood vessels, causing subsequent systemic vasculitis (1, 2).
In addition, M-proteins, especially those that are also cryoglobulins, can precipitate and cause erroneous measurements via several methods (1).
The drawing of blood into a prewarmed syringe or red-top tube is especially important if a high thermal amplitude cryoglobulin is suspected.
If diagnostic cryoglobulin deposits are present, a definitive diagnosis can be established.
In their protocol for the investigation of cryoglobulins, the authors advocate the use of the "cryocrit" as a means of quantifying and typing the cryoglobulin in question.
It has been hypothesized that the association between cirrhosis and MC may be due to the association of cryoglobulin with longstanding HCV infection and older age.
We soon began to investigate IgM function as well because we were studying a Waldenstrom protein that formed a mixed cryoglobulin with IgG and set about to determine whether the cryoglobulin was an antibody-antigen complex.
The routine use of prewarmed blood collection equipment and serum separation at 37 C is recommended for cryoglobulin assay specimen collection by Moroz and Rose.
We requested further workup, including complement measurements [complement 3 (C3) and C4], serum protein electrophoresis, a cryoglobulin screen, and viral serology analysis (HIV, hepatitis B virus, HCV).
Fibrinogen, antithrombin III, cryoglobulin, and cryofibrinogen levels were normal.
Bence Jones cryoglobulinuria: characterization of a urinary kappa light chain cryoglobulin [Letter].
Smoker Yes Cryoglobulin Positive, with no symptoms of mixed cryoglobulinemia Patient 2 Our patient Age and sex 58 F 46 M Chronic hepatitis duration (Yr) 11 1 Rheumatic symptoms None None ANA Negative Negative RF Positive (c) Positive Complement Normal Normal Anti-HCV Positive Positive Serum HCV RNA Positive Positive Symptoms and signs Dyspnea, cough Dyspnea, cough Clinical follow-up Stable with no Amelioration after therapy steroid therapy Smoker No Yes Cryoglobulin Positive, with Negative no symptoms of mixed cryoglobulinemia (a) HCV, hepatitis C virus; DIP, desquamative interstitial pneumonia; ANA, antinuclear antibody; RF, rheumatoid factor.