cryoglobulin


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cryoglobulin

[¦krī·ō′gläb·yə·lən]
(pathology)
An abnormal protein, usually an immunoglobulin, which precipitates from plasma between 40 and 70°F (4.4 and 21°C).
References in periodicals archive ?
Consequently, we found this rare disease suitable for presentation due to the fact that the plaques placed on the trunk and cryoglobulin positivity were in combination.
It occurs when cryoglobulins - abnormal proteins in the blood - thicken and clump together, restricting blood flow to surrounding organs and causing damage to blood vessels.
Although the link between mixed cryoglobulinemia and PN is well-known, the lack of cryoglobulin measurements is one limitation of our study
In addition, M-proteins, especially those that are also cryoglobulins, can precipitate and cause erroneous measurements via several methods (1).
This virus infects and provokes dysfunction in B-lymphocytes, which is primarily associated with the production of cryoglobulin, NOSA, and B-NHL.
For the exclusion of other causes of peripheral neuropathy, subsidiary tests were conducted, including: full blood count, erythrocyte sedimentation rate, C-reactive protein, fasting glucose and at 2 hours following 75 g of oral glucose; renal and hepatic function tests, TSH and free T4; B12 vitamin and homocystine; HIV and HTLV1 and 2, VDRL; cryoglobulin studies; serum protein electrophoresis; rheumatoid factor; anti-Ro (SS-A) and anti-Ro (SS-B).
7,8) The paraprotein may also have autoantibody or cryoglobulin activity resulting in autoimmune phenomena or cryoglobulinemia.
A hypercoagulable workup (protein C, protein S, factor II mutation, antithrombin III level, lupus anticoagulant, MTHFR mutation, cryoglobulin, homocystine, cardiolipin antibody, lipoprotein (a), beta-2 glycoprotein) showed abnormality of Factor V Leiden with heterozygousity for R506Q polymorphism.
High-potency antihaemophilic factor concentrate prepared from cryoglobulin precipitate.
Four months before final admission, the patient developed renal failure and underwent a kidney biopsy interpreted as mesangial proliferative glomerulonephritis with no evidence of cryoglobulin deposition.