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Related to cryptococcosis: histoplasmosis


see fungal infectionfungal infection,
infection caused by a fungus (see Fungi), some affecting animals, others plants. Fungal Infections of Human and Animals

Many fungal infections, or mycoses, of humans and animals affect only the outer layers of skin, and although they are sometimes
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(European blastomycosis), a deep-systemic fungal disease of man and animals caused by the yeastlike fungus Cryptococcus neoformans.

Cryptococcosis is a rare and serious disease, found in all countries. The sources of infection for man and the paths of dissemination of the pathogenic principle are unknown.

In man, cryptococcosis is characterized by predominant affection of the lungs, central nervous system, skin, and subcutaneous tissue, with subsequent metastases to the viscera. Diagnosis of the disease is difficult; laboratory diagnosis consists in isolation of the causative agent. The disease is treated medicinally (amphotericin B), combined with anticryptococcal rabbit serum or gamma globulin.

In animals, cryptococcosis is widespread in the USA, Denmark, Italy, France, and the Netherlands, and it has been recorded in Switzerland and the USSR. Cattle, cats, dogs, and monkeys are affected. The causative agent enters the animal’s body through the respiratory and digestive tracts. In cattle, cryptococcosis produces alternate chills and fever, swelling and soreness in the udders, a sharp decrease in milk production, and, with metastasis to the lungs, pneumonia. In dogs and cats, it affects the lungs and central nervous system. The diseased animals show disturbances of coordination, labored breathing, cough, and, occasionally, blindness. Treatment has not been developed. Zoo-hygienic and sanitary measures are of decisive importance in preventing cryptococcosis in animals.


Spesivtseva, N. A. Mikozy i mikotoksikozy, 2nd ed. Moscow, 1964.


A yeast infection of humans, primarily of the central nervous system, caused by Cryptococcus neoformans. Also known as torulosis.
References in periodicals archive ?
Cryptococcosis is a chronic or subacute fungal infection that has respiratory, meningitic, or systemic effects.
In experimental cryptococcosis when using animal models, extracellular PHA as a virulence factor for C neoformans has already been demonstrated.
The use of a serum CLAT should aid in diagnosing disseminated cryptococcosis and alert clinicians to the possibility of underlying cryptococcal pneumonia.
Although culture was not successful, the diagnosis of cryptococcosis was supported by results of multiple conclusive cytologic samples, blood antigen latex agglutination testing, PCR testing and sequencing, and eventual necropsy findings with histopathologic confirmation.
Previously diagnosed Cryptococcosis patients on fluconazole therapy and satisfying the above criteria.
The patients were classified into three groups: (a) PJP (19 cases): included patients with PJP and patients with diagnosis of PJP plus another pulmonary infection/disease; (b) patients with CAP (18 cases); and (c) other diagnosis (23 cases of lower respiratory infection: nine cases of tuberculosis, five cases of histoplasmosis, two cases of nocardiosis, one case of cryptococcosis, one case of disseminated strongyloidiasis, one case of pulmonary embolism, and three undiagnosed cases).
Cryptococcosis in horses is associated mainly with lesions in the respiratory tract, central nervous system (CNS), and abortion.
A significant proportion of patients with cerebral cryptococcosis are immunocompetent.
Primary cutaneous cryptococcosis due to cryptococcus neoformans var.
Death records were accessed when the ICD-10 code matched any of the following (or their subsections): aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mucormycosis, pneumocystosis, sporotrichosis, zygomycosis, and unspecified mycosis.
The condition was diagnosed as oral cryptococcosis based on culture and therapeutically managed with Ketoconazole and topical application of Povidone iodine.