Continuous activation of neutrophils, coupled with extensive circulating immune complexes, may predispose the host to a severe neutrophilic cutaneous reaction
Hand-foot syndrome is a cutaneous reaction
involving redness, peeling, blisters and intense pain on the palms of hands or the soles of feet.
Employing a simple strategy to evaluate the cutaneous reaction
of an EPP patient to the laparoscopic light source gave maximal reassurance that laparoscopic cholecystectomy would not provoke intra-peritoneal complications.
PCA reaction: An IgE-dependent cutaneous reaction
was generated by sensitizing the skin with an intradermal injection of anti-DNP IgE followed 48 h later with an injection of DNP-HSA into the mice tail vein.
Containing more than 35,000 adverse reactions, drug eruptions and cutaneous reaction
patterns, the book includes prescription and over-the counter drugs and well as biologics and supplements.
Severe cutaneous reaction
was defined as: diffuse maculopapular rash with vesicles, limited number of bullae or superficial ulceration of mucous membranes limited to one site (grade 3); or the presence of generalised bullous lesions, SJS, or toxic epidermal necrolysis (grade 4).
The patient experienced infiltration at the site of the intravenous hirudin infusion during his therapy and subsequently developed a cutaneous reaction
at this site.
If a patient develops an exfoliative cutaneous reaction
, VFEND should be discontinued.
Patterns to Drugs Clinical Pattern Selected Drug Examples Acneiform lithium, corticosteroids, androgens Lichenoid thiazides, antimalarials, captopril Fixed drug eruption tetracyclines, sulfonamides, barbiturates Morbilliform beta-lactam antibiotics, calcium channel blockers Urticarial beta-lactam antibiotics, aspirin Pityriasis rosea-like captopril, gold Pigmentation minocycline, antimalarials, bleomycin Subacute lupus-like hydrochlorothiazide, terbinafine Systemic lupus-like procainamide, hydralazine, minocycline Serum sickness-like cefaclor, minocycline Pemphigus-like captopril, penicillamine Pseudoporphyria naproxen, furosemide Photosensitivity doxycycline, thiazides, sulfonylureas Source: Dr.
Differentiating a serious reaction from one that is less serious may be difficult, particularly when evaluating a patient with a cutaneous reaction
Bardin stressed, it's vital to stop allopurinol when a cutaneous reaction
occurs--and to never reintroduce the drug.
Grade 3 cutaneous reactions
characterized by bullous, blistering, and exfoliating lesions occurred in 6 (0.