The pattern of cutaneous reactions
differs among various drugs.
Vaccination with VACV is administered by scarification of the skin which causes characteristic focal lesions that are indicative of successful vaccination, otherwise known as a major cutaneous reaction
, or take (7,8).
For the first-line treatment of epilepsy, drugs such as phenytoin (PHT), carbamazepine (CBZ), valproic acid, and lamotrigine are commonly used antiepileptic drugs (AEDs) that may give rise to cutaneous reactions
ranging from a skin rash to unexpected life-threatening adverse events.
The present study was done to see the clinical spectrum of adverse cutaneous reactions
and their causative drugs in our hospital.
Severe cutaneous reaction
was defined as: diffuse maculopapular rash with vesicles, limited number of bullae or superficial ulceration of mucous membranes limited to one site (grade 3); or the presence of generalised bullous lesions, SJS, or toxic epidermal necrolysis (grade 4).
DRESS consists of at least three of the following symptoms: cutaneous reaction
, eosinophilia, fever, and lymphadenopathy; and at least one systemic complication, such as hepatitis, nephritis, pneumonitis, myocarditis, pericarditis, and pancreatitis.
Rare but serious drug reactions include a severe cutaneous reaction
, hypersensitivity syndrome reaction, serum sickness-like reaction, and isolated single-organ dysfunction (SOR: B, systematic review).
The patient experienced infiltration at the site of the intravenous hirudin infusion during his therapy and subsequently developed a cutaneous reaction
at this site.
The incidence of developing a cutaneous reaction
increases with the number of the drugs taken.
Patterns to Drugs Clinical Pattern Selected Drug Examples Acneiform lithium, corticosteroids, androgens Lichenoid thiazides, antimalarials, captopril Fixed drug eruption tetracyclines, sulfonamides, barbiturates Morbilliform beta-lactam antibiotics, calcium channel blockers Urticarial beta-lactam antibiotics, aspirin Pityriasis rosea-like captopril, gold Pigmentation minocycline, antimalarials, bleomycin Subacute lupus-like hydrochlorothiazide, terbinafine Systemic lupus-like procainamide, hydralazine, minocycline Serum sickness-like cefaclor, minocycline Pemphigus-like captopril, penicillamine Pseudoporphyria naproxen, furosemide Photosensitivity doxycycline, thiazides, sulfonylureas Source: Dr.