cyclase


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Related to cyclase: Guanylate cyclase

cyclase

[′sī‚klās]
(biochemistry)
An enzyme that catalyzes cyclization of a compound.
References in periodicals archive ?
Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade.
i]-adenylyl cyclase signaling complex as a representative G protein-coupled receptor system to study the influence of environmental factors (Murray and Siebenaller, 1987; Siebenaller and Murray, 1988, 1990, 1995).
With its medical use and composition of matter patents the Company has a dominant position in the area of glutaminyl cyclase inhibition.
Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung.
Yeast lacking adenylate cyclase -- the enzyme that makes cyclic AMP, a small regulatory molecule--cannot begin cell division.
It binds to guanylate cyclase C locally in the intestine, with no measurable blood plasma concentrations, resulting in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).
This partnership will utilise Lonza's expertise for the development of a cost-effective, scalable and robust suspension culture-based adenovirus manufacturing platform, which is likely to allow the production of sufficient material to meet the potential demand for promising gene therapies such as RT-100, an investigational product that uses a non-replicable viral vector - adenovirus 5 - to deliver a therapeutic gene encoding the protein AC6 (adenylyl cyclase type 6) directly to the heart tissue during a routine outpatient procedure without the need for surgery.
At the same time, Merck has also inked clinical development collaboration deal with Bayer to market and develop its portfolio of soluble guanylate cyclase (sGC) modulators including Adempas (riociguat) and vericiguat.
Of these, the pathway synthesizing cyclic AMP (cAMP), controlled by adenylyl cyclase, appears to be among the most prominent sites for disruption by chlorpyrifos (Meyer et al.
Altered vascular norepinephrine responses in portal hypertensive intestine: role of PKA and guanylate cyclase.
Cyclase (lot 1) and three and conversions in solid case design (lot 2)