cyclic GMP


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cyclic GMP

[¦sī·klik ¦jē¦em′pē]
(biochemistry)
A 3′,5′-cyclic ester of guanosine monophosphate that is involved in vision transduction through its direct effects on Na+and Ca2+channels in the plasma membrane of rod cells.
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References in periodicals archive ?
Then the researchers used isolated fat cells and treated the cells directly with cyclic GMP and identified a "browning" effect as well.
5 NATURE, however, two research groups--those of Yau and of Cobbs and Pugh -- report that cones of catfish and of larval tiger salamander do use cyclic GMP as a messenger.
In both rods and cones the action of cyclic GMP is a biochemical novelty.
The same concentrations of Aptosyn(R), CP461, and CP248 that cause an increase in cyclic GMP and induce death by apoptosis in human colon cancer cells also lead to phosphorylation of VASP," said W.
SAANDs selectively trigger apoptosis in cancerous and precancerous cells by inhibiting certain cyclic GMP phosphodiesterases that company scientists and collaborators have shown to be over-expressed in a variety of tumor types.
The results of this study continue to support clinical proof-of-principle for exisulind, a cyclic GMP phosphodiesterase inhibitor, in the prevention of growth of precancerous adenomatous polyps of the colon," said Rifat Pamukcu, MD, chief scientific officer of Cell Pathways, Inc.
In studies of diseased canine and human tissues, high levels of cyclic GMP phosphodiesterases (cGMP PDE) of the PDE2 and PDE5 gene families have been detected (both molecular targets for CP461) in activated macrophages associated with IBD.
In previous research, we have shown that exisulind, CP461, and CP248 selectively inhibit cell growth and trigger apoptosis in a number of human cancer types, through inhibition of cyclic GMP phosphodiesterases 2 and 5," said lead author I.
Cell Pathways scientists and their collaborators have demonstrated that SAANDs exert their apoptotic effects by inhibiting certain cyclic GMP phosphodiesterases that are over-expressed in a variety of tumor types.
Nasdaq:CLPA) today released data demonstrating the presence, in breast cancer cells, of the cyclic GMP phosphodiesterases (cGMP PDEs) targeted by their selective apoptotic antineoplastic drugs (SAANDs).

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