Except for the G2/M phase, a similar pattern of cyclin
and CDKI expression was observed in the controls and MM patients.
The impact of incorporating cyclin
D1 analysis in the future decision making paradigm in the management of OSCC has several benefits.
CDK activity throughout the cell cycle is highly regulated by association with cyclins
and with inhibitory proteins (Oogood, 2002).
Gene Alteration p53 Overexpression p21WAF1 Overexpression Cyclin
D1 High expression Cyclin
E High expression Cdk2 High expression Table 2.
Western blots were carried out to demonstrate p53 transactivation of p21, PCNA, Cyclin
G, mdm2 and bcl2 genes for both rat liver cells and Hep G2 cell line.
Based on these results, cyclin
B levels, the cyclin
which regulates entrance into mitosis, requires further study in U138 and U373.
Previous research has shown that Cyclin
A is expressed in a small number of neurons including a cluster of seven neurons on each side of the brain.
This down-regulation occurred via the suppression of either cyclin
E/CDK2 or cycl in H/CDK7, while apoptosis was induced through the modulation of the Ala-1-related signaling pathway.
D1 is a key regulatory protein at G1/S checkpoint of the cell cycle.
To investigate the utility of Ki-67 and other cell cycle regulatory proteins (S-phase kinase-associated protein 2 [Skp2], p27, and cyclin
D1) in the differential diagnosis of mammary vascular lesions.
Osaka, Japan) has patented a novel protein having a high degree of homology to the amino acid sequence of the so-called cyclin
box which is characteristic of cyclins
: they are herein referred to as "human cyclin
I" or "human cyclin
Other observations suggest that the role of arsenic as a cocarcinogen may be mediated by inhibition of DNA repair and increased expression of cyclin
D1 (Vogt and Rossman 2001).