cyclization

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cyclization

[‚sī·klə′zā·shən]
(organic chemistry)
Changing an open-chain hydrocarbon to a closed ring.
References in periodicals archive ?
The compound 1 was condensed with acetophenone, p-methoxyacetophenone or p-nitroacetophenone using piperidine as a catalyst in the presence of ethanol as a solvent afforded polyfunctionally substituted intermediate compound 18, which is anticipated to cyclize into 2,5-dihydro-2-imino-4-phenyl-5-(1-phenylethylidene)thiophene-3-carbonitrile derivatives 19a-c.
Compound 1 boils with a mixture of acetic acid/acetic anhydride gives the intermediate compound 2 which cyclizes to 5-acetyl-2-amino-4-phenylthiophene-3-carbonitrile 3.
Poly(amic acid) groups can suffer three types of transformations upon heating: the group can cyclize itself to produce either an isoimide group, an imide group, or to regenerate an anhydride molecule.
In contrast, more than 99% of aldosterone cyclizes, with the alde- hyde group at carbon 18 reacting with the hydroxyl at carbon 11, forming a stable 11,18 hemiacetal.
In the absence of Cu, the bisozaxoline-modified bisthiophene cyclizes without any control of stereochemistry, giving equal mixtures of the (S,S)-(R,R) and (S,S)-(S,S) diastereomers.
Glutaminyl cyclase cyclizes N-terminal glutamine to pyroglutamic acid in such peptides as TRH.
For example, glutaminyl cyclase (QC) cyclizes N-terminal glutamine to pyro-glutamine to produce a biologically active peptide.