The proposed method can be used successfully for routine analysis of cyclizine hydrochloride in pure and in dosage forms.
Keywords: Cyclizine hydrochloride, m-dinitrobenzene, spectrophotomerty.
Cyclizine hydrochloride is a piperazine derivative (Fig.
The idea behind the study was to develop a new spectrophotometric method for the determination of cyclizine hydrochloride in pure and its dosage forms.
Absorption Spectrum of Coloured Complex Cyclizine hydrochloride reacts with m- dinitrobenzene at 100degC in basic media to give purple complex, the absorption spectra of which under optimum conditions lies at 540 nm (Fig.
The results for the determination of cyclizine hydrochloride are shown in Table-1 and 2, which show the sensitivity, validity and repeatability of the method.
Table-1: Determination of cyclizine hydrochloride from pure solution.
cyclizine hydrochloride cyclizine hydrochloride Relative standard