cyclooxygenase


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cyclooxygenase

[‚sī·klō′äks·ə·jə‚nās]
(biochemistry)
An enzyme that catalyzes the conversion of arachidonic acid into prostaglandins.
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References in periodicals archive ?
Fraction 1, active in the cyclooxygenase inhibitory assay, was further purified by preparative HPLC, on two Jaigel S-343-15 ODS columns in tandem, under gradient conditions using MeOH-ACH-[H.
Key words: Echinacea purpurea, alkamides, cyclooxygenase, enzyme, Aedes aegyptii, mosquitocidal
Key words: antioxidant, cyclooxygenase, topoisomerase, Apium graveolens, Apiaceae
25] Prostaglandins are synthesized from arachidonic acid by the action of cyclooxygenases (COXs).
At higher concentrations, 7-epiclusianone induces a contractile effect where cyclooxygenase and 5-lipoxygenase-derived products are involved.
Effects of nitric oxide synthase and cyclooxygenase inhibitors, and muscarinic receptor antagonist on Ch1LW-induced relaxation
FAF and compounds 1-3 showed cyclooxygenase (COX) enzyme inhibitory and antioxidant activities.
This is also true for the signal transduction pathways, for example cyclooxygenase 2 (Cox-2), HER2/neu, mitogen-activated protein kinase (MAPK), and PI3K/Akt.
The finding confirmed the gastrointestinal advantages of the cyclooxygenase (COX)-2 inhibitor.
Each of the extracts was tested for its ability to inhibit the key pro-inflammatory enzymes - cyclooxygenase 1 [COX1], cyclooxygenase 2 [COX2], and 5-lipooxygenase [5-LOX] - that are known contributors to impaired joint health, pain, and arthritis.
In animal models, the cyclooxygenase 2 inhibitor celecoxib, better known by its brand name Celebrex, inhibits the development of ultraviolet-induced pre-malignant skin papillomas, which are thought to correspond to actinic keratoses, the pre-malignant precursor of non-melanoma skin cancers