His Honours and subsequent MSc research spawned a lifelong interest in cyclophane
Polyaza macrobicyclic cryptands: synthesis, crystal structures of a cyclophane
type macrobicyclic cryptand and of its dinuclear copper(I) cryptate, and anion binding features.
The researchers find that by attaching a photosensitive compound to the cylinder, a cyclophane
, they can use light to make it expel the piston, a bis-naphthalene.
Bodwell at Memorial University of Newfoundland in the field of cyclophane
His Honours and subsequent MSc research with Reg Mitchell, FCIC, spawned a lifelong interest in cyclophane
Not only is their synthesis the shortest, it is also elegant in design, using a cycloaddition of a preformed cyclophane
that generates a complex pentacyclic core in one step.
and cage (polycyclic) alkanes are chosen due to their peculiar structures and intriguing charge transfer properties.
To mimic the active site, macrocyclic compounds such as cyclodextrins , crown ether , cyclophanes
and calixarenes , each having an inclusion cavity as a basic skeleton of potent artificial monooxygenase, were usually employed.
A wide range of structures synthesised over the past few decades are covered, from the simpler cyclophanes
and multi-ring aromatic structures to vases, bowls, cages and more complex multi-ring systems and 3D architectures such as pumpkins, interlocking chains and knots.
He demonstrated how these principles can be used to create novel molecular architectures such as cyclophanes
Yuan successfully synthesized numerous novel imidazole functionalized ligands and cyclophanes
, and undertook comprehensive investigation of their molecular recognition activities.
in the Synthesis of Non-natural and Natural Products.