His Honours and subsequent MSc research spawned a lifelong interest in cyclophane
Polyaza macrobicyclic cryptands: synthesis, crystal structures of a cyclophane
type macrobicyclic cryptand and of its dinuclear copper(I) cryptate, and anion binding features.
The researchers find that by attaching a photosensitive compound to the cylinder, a cyclophane
, they can use light to make it expel the piston, a bis-naphthalene.
Bodwell at Memorial University of Newfoundland in the field of cyclophane
His Honours and subsequent MSc research with Reg Mitchell, FCIC, spawned a lifelong interest in cyclophane
Not only is their synthesis the shortest, it is also elegant in design, using a cycloaddition of a preformed cyclophane
that generates a complex pentacyclic core in one step.
Achillion informed that this patent is entitled "Substituted aliphanes, cyclophanes
, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating HCV infections," and provides a patent term which lasts until 2032.
A wide range of structures synthesised over the past few decades are covered, from the simpler cyclophanes
and multi-ring aromatic structures to vases, bowls, cages and more complex multi-ring systems and 3D architectures such as pumpkins, interlocking chains and knots.
He demonstrated how these principles can be used to create novel molecular architectures such as cyclophanes
Yuan successfully synthesized numerous novel imidazole functionalized ligands and cyclophanes
, and undertook comprehensive investigation of their molecular recognition activities.
in the Synthesis of Non-natural and Natural Products.
Russell Bell, FCIC, widely known for his early studies of the use of the nuclear Overhauser effect in organic structure elucidation by NMR, is currently involved with the synthesis and NMR spectroscopy of heteroaromatic cyclophanes
, focusing on the aromatic heterobases present in RNA and DNA.