cyclophilin


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cyclophilin

[‚sī·kə′fil·ən]
(biochemistry)
An abundant cytoplasmic protein that catalyzes cis-trans isomerizations; it has a high affinity for the immunosuppressive drug cyclosporin A.
References in periodicals archive ?
The Cyclophilin A (CypA) is conventional protein reported in bacteria, fungi, plants and mammals (Galat, 1999).
Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein.
The optimized conditions consisted of TGFB1 or COL1, 250 nM primers, and 250 nM probes, with 1 [micro]L cyclophilin.
Other proteins that are strictly cytoplasmic include cyclophilin A (a plant immunophilin), which is restricted to cell organelles: its presence in the drop is likely due to cell death and subsequent leakage of cellular contents.
4% of the follow-up samples, of which two-thirds showed overexpression of the cyclophilin C gene (PPIC), and just a few by EpCAM overexpression.
Other nonDAA agents, such as host cyclophilin inhibitors, also figure in the mix.
20) Cyclophilin inhibitors (such as mycophenolic acid and cyclosporine A) have shown strong inhibition of MERS-CoV replication in vitro.
Six candidate reference genes, namely glyceraldehyde 3-phosphate dehydrogenase (GAPDH), beta-actin (ACTB), beta-2-microglobulin (B2M), ribosomal protein L4 (RPL4), TATA-box binding protein (TBP) and cyclophilin A (PPIA), were selected from the most commonly used ones reported in previous studies (Martino et al.
4) The BAFF is produced by myeloid lineage cells, malignant B cells, activated T cells, and bone marrow stromal cells (5) and has three receptors that belong to the TNF receptor superfamily: the B cell maturation antigen (BCMA), the transmembrane activator, calcium-modulator and cyclophilin ligand interactor (TACI), and the BAFF receptor (BAFF-R).
179) In splenocyte culture, however, anti-ganglioside antibodies were produced in the presence of a soluble transmembrane activator and calcium-modulating and cyclophilin ligand interactor immunoadhesin, a receptor for B-cell-activating factor belonging to the tumor necrosis factor family.
A team of scientists from the University of Rochester, the University of Southern California, and other institutions found that ApoE4 works through cyclophilin A, a well-known bad actor in the cardiovascular system, causing inflammation in atherosclerosis and other conditions.