Cytoxan

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Related to cyclophosphamide: vincristine

Cytoxan

(sītŏk`sĭn), trade name for the drug cyclophosphamide, used to inhibit growth of tumors and rapidly proliferating cells. It is used in the treatment of leukemia, Hodgkin's disease, and lymphosarcoma and other solid tumors. A drug of great specificity, Cytoxan is activated in the body by the enzymes in certain types of tumors. Because it is also activated in such tissues as blood plasma and liver, it is a highly toxic substance. Nevertheless, it is a potent and useful chemotherapeutic agent.
References in periodicals archive ?
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis.
Cyclophosphamide may be considered if diffuse alveolar hemorrhage is refractory to steroids.
Immunogenic chemotherapy agents commonly used in the treatment of breast cancer include cyclophosphamide, anthracyclines (such as doxorubicin) and gemcitabine.
Seventy-five weeks after initial presentation and 29 weeks after the initiation of cyclophosphamide, Hurricane Katrina disrupted routine husbandry and medical care at the zoological facility.
The total group of 316 women included 76 who were treated with cyclophosphamide, of whom 33% developed PGF.
Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation.
Cyclophosphamide is continued for approximately 12 months.
The efficacy of oral cyclophosphamide and prednisone is well established for management of AASV.
Specifically, 22% of the patients on mycophenolate mofetil versus 6% of those on IV cyclophosphamide met the American College of Rheumatology criteria for complete remission (N.
1) Among the many treatments for CIDP are plasmapheresis, intravenous immunoglobulin (IV Ig), corticosteroids, and other immunomodulators such as azathioprine, cyclosporine, and cyclophosphamide.
However, mice treated with one dose of cyclophosphamide demonstrate inflammatory changes in the brain.
That treatment was followed in one group by injection of saline and in a second group of the drug cyclophosphamide at a dose that prolonged the animals survival.