cyclosporin A


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Related to cyclosporin A: methotrexate, tacrolimus, Statins

cyclosporin A

[¦sī·klə‚spȯr·ən ′ā]
(biochemistry)
A cyclic peptide produced by some fungi. It inactivates helper T cells, making it useful as an immunosuppressive drug, especially in the prevention of graft rejection in transplantation surgery.
References in periodicals archive ?
Tacrolimus is a macrolide antibiotic isolated from Streptomyces tsucrenaenseis, which is 10 to 100 times more potent in vitro than cyclosporin A.
Within this group are immunosuppressive drugs like cyclosporin A, which act directly against special cells of the immune system.
Simultaneous and rapid analysis of cyclosporin A and creatinine in finger prick blood samples using liquid chromatography tandem mass spectrometry and its application in C2 monitoring.
Clinical stability was defined as the absence of acute rejection, febrile infection, and cyclosporin A toxicity, as well as stability of creatinine clearance as estimated by the formula of Cockroft and Gault (27).
1 Part of the success was due to the FDA approval in 1983 of cyclosporin as an immunosuppressive and antirejection drug.