cyclosporin A

(redirected from cyclosporine)
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cyclosporin A

[¦sī·klə‚spȯr·ən ′ā]
(biochemistry)
A cyclic peptide produced by some fungi. It inactivates helper T cells, making it useful as an immunosuppressive drug, especially in the prevention of graft rejection in transplantation surgery.
References in periodicals archive ?
12] concentrations, and treatment with cyclosporine or tacrolimus.
Her medications on admission included cyclosporine (100 mg twice a day), azathioprine (150 mg once a day), prednisone (10 mg once a day), verapamil (240 mg each morning and 120 mg each evening), furosemide (80 mg once a day), potassium chloride (10 mEq once a day), clonidine (0.
Another 18 mice injected with the same type of cancer cells and cyclosporine each developed an average of 338 cancers in their lungs.
When Rapamune is taken with cyclosporine or tacrolimus, you may develop a blood clotting problem resulting in unexplained bleeding or bruising.
Beginning with a pilot trial in 1996 that included 11 patients, Finnish investigators evaluated cyclosporine, which has been used with variable success in almost all autoimmune diseases.
Cararach and colleagues at the University of Barcelona compared 27 patients who were treated with azathioprine and prednisone (1973-1991) and 32 patients who were treated with cyclosporine and prednisone (1992-2007).
The FDA approval announcement noted Prograf offers an alternative to cyclosporine for use in certain combination immunosuppressive regimens in liver, kidney and heart transplantation.
In this analysis of the Rapamune Maintenance Study, 430 kidney transplant patients were randomly assigned to remain on sirolimus (SRL), cyclosporine (CsA) and steroids (ST) or to have cyclosporine withdrawn.
However, no cyclosporine data were exhibited in their paper, and the stability was monitored for only 24 h.
Miller's own unpublished research, funded in part by MDA, suggests that cyclosporine temporarily improves muscle strength in boys with Duchenne's muscular dystrophy.
NeuroVive is a public pharmaceutical company in Lund, Sweden, producing NeuroSTAT[R], a patented intravenous cyclosporine formula to treat traumatic brain injury, and has world patents for cyclosporine neuroprotection against acute neurological diseases.
ZURICH -- Combining a supervised weight-loss diet with substandard-dose cyclosporine in obese patients with severe chronic plaque psoriasis makes for very effective therapy, Dr.