cystamine


Also found in: Medical, Wikipedia.

cystamine

[′sis·tə‚mēn]
(organic chemistry)
(CH2)6N4 A white, crystalline powder, melting at 280°C; used to make synthetic resins. Also known as aminiform; crystogen; cystamine methenamine; hexamethylene tetramine; urotropin.
References in periodicals archive ?
Protein A, cystamine dihydrochloride, and concanavalin A (ConA) were purchased from Sigma.
tHcy and tCys in EDTA plasma were analyzed simultaneously by HPLC after the reduction of plasma disulfides with tris(2-carboxyethyl)phosphine, precipitation of proteins with trichloroacetic acid, derivatization with 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F), and fluorescent detection as described previously (10) using cystamine as an internal standard.
We previously directly compared results obtained with these two reducing agents and found that although the use of TCEP produced higher relative fluorescence intensities, the calculated concentrations of plasma tHcy were not significantly different if calibration was performed in plasma and cystamine was used as the internal standard (7).
6), as the reducing agent, cystamine as the internal standard, and isocratic separation of the thiols extracted from only 50 /,L of plasma within 6 min.
Direct methods of preventing polyQ protein aggregation using molecules such as Congo Red and cystamine, which act to stabilise the native non-toxic conformation of the protein, prevent cross-linking of the mutant isoform, or promote clearance from the cell, have also been attempted.
In treatment groups cystamine was supplemented at three levels (0, 100, 500 [micro]M).