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cytochalasin |
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cytochalasin [¦sīd·ō·kə′lā·sən] (biochemistry) One of a series of structurally related fungal metabolic products which, among other effects on biological systems, selectively and reversibly block cytokinesis while not affecting karyokinesis; the molecule with minor variations consists of a benzyl-substituted hydroaromatic isoindolone system, which in turn is fused to a small macrolide-like cyclic ring. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| University researchers have successfully packaged Cytochalasin B -- a potential cancer drug -- in liposomes so that it is released gradually and its toxocity to healthy tissue is reduced. The company also has patents relating to the biological stenting of traumatized blood vessels by administration of cytoskeletal inhibitors such as cytochalasins (Biostent(R) therapy). To inhibit phagocytic uptake, cells were pretreated with cytochalasin D (cytD, 10 [micro]g/mL; Fluka) for 30 min and during incubation with particles (Thiele et al. |
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