First, we confirmed the cytocidal
effect of hypotonic shock induced by sterile water on bladder cancer cells.
For instance, Artepilin C (3,5-diprenyl-4-hydroxycinnamic acid) exhibits potent cytocidal
effects and induces marked levels of apoptosis which may be partially associated with enhanced Fas receptor expression and loss of the mitochondrial membrane potential in human leukemia cell lines in vitro (Kimoto et al.
Potent membrane-permeabilizing and cytocidal
action of Vibrio cholerae cytolysin on human intestinal cells.
ATP assay: ability to distinguish cytostatic from cytocidal
anticancer drug effects".
STUDY SUMMARY: The goals of the study were to evaluate the over-all safety and efficacy of intravenous infusions of Rexin-G, a tumor-targeted retrovector bearing a cytocidal
anti-cyclin G1 construct, in chemo-therapy-resistant bone and soft tissue sarcoma.
Thus, analysis of the expression of the genes encoding these 2 proteins may reveal an association with the cytostatic and cytocidal
effects of drugs, similar to the bacteriostatic and bacteriocidal effects of antibiotics.
Additionally, the antibodies tested were cytostatic in vitro but cytocidal
in vivo, indicating that the host environment may also play an important part in defining anti-tumour activity.
cell culture tests for the presence of certain cytocidal
viruses (by inoculation of and blind passage in Vero, MRC-5, HeLa, RK, and A9 cells with observations for cytopathology and tests for hemadsorption and hemagglutination at the end of the culture period), and animal inoculation tests for certain viruses (suckling and adult mice, guinea pigs, and embryonated hen eggs).
IFN-[gamma] induces various pro-inflammatory cytokines and biochemical pathways including the expression of distinct enzymes such as GTP-cyclohydrolase I (GTP-CH1) and indoleamine 2,3-dioxygenase (IDO), as well as the formation of cytocidal
reactive oxygen species (ROS) by human monocytes/macrophages and other immune effector cells (Fig.
SUMMARY: Rexin-G and Reximmune-C are tumor-targeted retrovectors bearing a cytocidal
anti-cyclin G1 construct and a controllable GM-CSF expression construct, respectively.
Coronavirus infections can be cytocidal
for the cells; or, in some cases, persistent infection can result (17).
and cytostatic chemosensitivity test by measuring total amount of mRNA.