cytosine

(redirected from cytosine arabinoside)
Also found in: Dictionary, Thesaurus, Medical, Acronyms.
Related to cytosine arabinoside: Daunorubicin

cytosine

(sī`tōsēn'), organic base of the pyrimidinepyrimidine
, type of organic base found in certain coenzymes and in the nucleic acids of plant and animal tissue. The three major pyrimidines of almost universal distribution in living systems are cytosine, thymine, and uracil.
..... Click the link for more information.
 family. It was isolated from the nucleic acidnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
..... Click the link for more information.
 of calf thymus tissue in 1894. A suggested structure for cytosine, published in 1903, was confirmed in the same year when that base was synthesized in the laboratory. Combined with the sugar ribose in glycosidic linkage, cytosine forms a derivative called cytidine (a nucleoside), which in turn can be phosphorylated with from one to three phosphoric acid groups, yielding the three nucleotidesnucleotide
, organic substance that serves as a monomer in forming nucleic acids. Nucleotides consist of either a purine or a pyrimidine base, a ribose or deoxyribose, and a phosphate group. Adenosine triphosphate serves as the principle energy carrier for the cell's reactions.
..... Click the link for more information.
 CMP (cytidine monophosphate), CDP (cytidine diphosphate), and CTP (cytidine triphosphate). Analogous nucleosides and nucleotides are formed from cytosine and deoxyribose. The nucleoside derivatives of cytosine perform important functions in cellular metabolism. CTP acts as a coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
..... Click the link for more information.
 in both carbohydrate and lipid metabolism; it can readily donate one of its phosphate groups to adenosine diphosphate (ADP) to form adenosine triphosphateadenosine triphosphate
(ATP) , organic compound composed of adenine, the sugar ribose, and three phosphate groups. ATP serves as the major energy source within the cell to drive a number of biological processes such as photosynthesis, muscle contraction, and the synthesis of
..... Click the link for more information.
 (ATP), an extremely important intermediate in the transfer of chemical energy in living systems. CTP is the source of the cytidine found in ribonucleic acid (RNA) and deoxycytidine triphosphate (dCTP) is the source of the deoxycytidine in deoxyribonucleic acid (DNA). Thus cytosine is intimately involved in the preservation and transfer of genetic information.

Cytosine

 

(also 2-hydroxy-6-aminopyrimidine), a natural organic compound. A pyrimidine base, cytosine occurs as white crystals or thin, lustrous platelets. Its molecular weight is 111.1. It is found in all living cells as a component of nucleotides—that is, compounds that form nucleic acids, coenzymes, and certain other biologically active substances. The nucleoside cytidine consists of cytosine and the carbohydrate D-ribose.

cytosine

[′sīd·ə‚sēn]
(biochemistry)
C4H5ON3 A pyrimidine occurring as a fundamental unit or base of nucleic acids.
References in periodicals archive ?
Cisplatin, cytosine arabinoside, chromomycin, 5-fluorouracil were obtained from Sigma Chemicals Co.
Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: a Cancer and Leukemia Group B study Blooel 1982;60:454-462.
After discussion with him and his wife he has elected to have palliative chemotherapy with low dose cytosine arabinoside.
3,12-17 It is described with the use of many chemotherapy agents like taxenes, 5-Fluoro uracil, epirubicin, cyclophosphamide, platinum derivatives, vinorelbine, ifosfamide, etoposide, pegylated interferon, cytosine arabinoside, vinca alkaloids, sulphasalazine, procainamide, gemcitabine, pemetrexed, and alemtuzumab.
The effects of cytosine arabinoside on RNA-primed DNA synthesis by DNA polymerase a-primase.
Another 20 cancer-inoculated rats received the same dose of cytosine arabinoside together with ImuVert.
A Pilot Study Poster Board #128-II Abstract 1951 Phase II Study of Clofarabine and Cytosine Arabinoside in Adult Patients with Relapsed AML and in Elderly Patients with Untreated AML Who Are at High Risk of Anthracycline Toxicity Poster Board #129-II Abstract 1963 Phase I Clinical-Laboratory Trial of Clofarabine (CLO) Followed by Cyclophosphamide (CY) for Adults with Refractory Acute Leukemias: Evidence for Enhanced DNA Damage.
Since the retroperitoneal mass persisted in follow-up abdominal CT, a new chemotherapy regimen containing fludarabine, cytosine arabinoside, and idarubicin was started.
Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and Daunorubicin.
The FDA approval followed a priority review and was based on 12-month data from a large head-to-head study comparing Gleevec with a combination of interferon-alpha and cytosine arabinoside (IFN/Ara-C), a traditional treatment for CML.
After immunohistochemical examination the patient was diagnosed with AML MO, and classic 7+3 induction chemotherapy regimen involving cytosine arabinoside and idarubicin combination protocol was initiated.