designating a cytotoxic
drug administration area, which only permits entry to authorised people.
Procedures that govern the use of cytotoxic
medications for oncology indications are also applicable when medications such as cyclophosphamide are used for non-oncology purposes.
According to Datamonitor oncology analyst, Chandni Surti, sales of the 25 cytotoxic
therapy cancer brands that are currently available in the seven major markets (7MM) in 2007 totalled $10bn.
Main features: Supply, installation and qualification of technical equipment iso (2 + (insulators main transfer + sterilizer)) for centralized preparation of cytotoxic
drugs in areas controlled atmosphere class D depression
The summary offers a high level view on the likely evolution of manufacturing of HPAPIs and cytotoxic
PharmSource researchers found that as an industry, CMOs have lost considerable capacity to manufacture cytotoxic
Results: Data on cytotoxic
effects could be obtained from primary cultures in 18 of the 27 recruited patients.
Several environmental agents activate MAP kinases to cause cellular stress and cytotoxic
responses, including bacterial products (such as lipopolysaccharide; LPS), pesticides, certain transition metals, and UV radiation (11-13).
Datamonitor insight into the cytotoxic
therapies market 3
This results in S-Phase depletion, greatly reducing the number of cancer cells killed by the S-Phase cytotoxic
The anti-VEGF monoclonal antibody, bevacizumab, increases the activity of a variety of active cytotoxic
regimens and it has been shown in randomised Phase III trials that when combined with irinotecan plus 5-fluorouracil (5-FU) / leucovorin (LV) in the first-line treatment of metastatic CRC and with FOLFOX (5-FU/LV/oxaliplatin) in second-line treatment, leads to an increased median survival, progression-free survival (PFS) and response rate (RR) compared to the cytotoxic
chemotherapy alone .
therapies are the second largest class of cancer therapeutics