cytotoxic


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to cytotoxic: cytostatic, cytotoxic agents, cytotoxic reaction, cytotoxic chemotherapy

cytotoxic

[¦sīd·ə′täk·sik]
(cell and molecular biology)
Pertaining to an agent, such as a drug or virus, that exerts a toxic effect on cells.
References in periodicals archive ?
designating a cytotoxic drug administration area, which only permits entry to authorised people.
Procedures that govern the use of cytotoxic medications for oncology indications are also applicable when medications such as cyclophosphamide are used for non-oncology purposes.
Main features: Supply, installation and qualification of technical equipment iso (2 + (insulators main transfer + sterilizer)) for centralized preparation of cytotoxic drugs in areas controlled atmosphere class D depression
The summary offers a high level view on the likely evolution of manufacturing of HPAPIs and cytotoxic drugs.
PharmSource researchers found that as an industry, CMOs have lost considerable capacity to manufacture cytotoxic injectable drugs.
Results: Data on cytotoxic effects could be obtained from primary cultures in 18 of the 27 recruited patients.
Several environmental agents activate MAP kinases to cause cellular stress and cytotoxic responses, including bacterial products (such as lipopolysaccharide; LPS), pesticides, certain transition metals, and UV radiation (11-13).
This results in S-Phase depletion, greatly reducing the number of cancer cells killed by the S-Phase cytotoxic.
The anti-VEGF monoclonal antibody, bevacizumab, increases the activity of a variety of active cytotoxic regimens and it has been shown in randomised Phase III trials that when combined with irinotecan plus 5-fluorouracil (5-FU) / leucovorin (LV) in the first-line treatment of metastatic CRC and with FOLFOX (5-FU/LV/oxaliplatin) in second-line treatment, leads to an increased median survival, progression-free survival (PFS) and response rate (RR) compared to the cytotoxic chemotherapy alone [3].
Cytotoxic therapies are the second largest class of cancer therapeutics