Doherty notes that investigators are now using cytotoxic T cells
to rid bone marrow transplants of viral infections and are designing vaccines, including those for AIDS, to generate these virus-killing cells.
Class I Tetramers, which are primarily used for vaccine development, accurately measure CD8 cytotoxic T cells
and have been marketed primarily to biopharmaceutical
In this preclinical study, human NK cells and cytotoxic T cells
were treated in vitro with interferon-alpha, with or without Ceplene.
The data, published in the December issue of Nature Biotechnology, highlights a method for modifying targets on cancer cells called antigens to facilitate activation of cytotoxic T cells
-- a key component of the immune system responsible for destroying cancerous cells.
Tumor antigens are the signals to the cytotoxic T cells
of the immune system that are responsible for killing tumor cells.