The carefully coordinated balance of methylation/demethylation as well as histone acetylation/ deacetylation
is what ultimately determines gene expression resulting from epigenetic environmental influences.
of chitin--a polysaccharide occurring abundantly in nature and extracted commercially from fish industry waste, such as crab and shrimp shells, among other sources--yields chitosan.
and phosphorylation of PGC-1[alpha] by SIRT1 and AMPK, respectively, are essential for PPAR transactivation (Canto et al.
of p53 is required for its degradation.
SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation
and inhibition of NF- B activity.
A proper balance of acetylation and deacetylation
is regulated by histone acetyltransferases (HAT) and histone deacetylases (HDACs), respectively.
Epigenetic Regulation of Uterine Biology by Transcription Factor KLF11 via Post-translational Histone Deacetylation
of Cytochrome p450 Metabolic Enzymes.
Malaysia) with degree of deacetylation
(DD) of 90%.
Chitosan is a natural polysaccharide biopolymer produced by alkaline deacetylation
Chitosan, as the most important derivative of chitin, can be prepared by deacetylation
2007) has been reported that porcine metaphase (MII) oocyte extract replaces transcription factors from donor nuclei with the oocyte extract and eventually increases the histone deacetylation
in the somatic nuclei.
Additionally, histone deacetylation
mediated by LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 (LSDI)--LIKE 1 (LDL1), a component of a plant corepressor complex, participates in the regulation of root elongation by repressing a root-specific gene, named LATERAL ROOT PRIMORDIUM 1 (LRP1).