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Related to Deamination: transamination, Oxidative deamination


(organic chemistry)
Removal of an amino group from a molecule.



the elimination of an amino group (NH2) from organic compounds. Deamination is accompanied by the substitution of some other group, such as H, OH, OR, or Hal, for the amino group or by the formation of a double bond. In particular, deamination is brought about by the action of nitrous acid on primary amines. In this reaction, acyclic amines yield alcohols (I) and olefins (II), for example:

The deamination of alicyclic amines is accompanied by ring expansion or contraction. In the presence of strong inorganic acids, aromatic amines and nitrous acid yield diazonium salts. Such reactions as hydrolysis, hydrogenolysis, decomposition of quaternary ammonium salts, and pyrolytic reactions also result in deamination.

Deamination plays an important part in the life processes of animals, plants, and microorganisms. Oxidative deamination, with the formation of ammonia and α-keto acids, is characteristic of d-amino acids. Amines also undergo oxidative deamination. Except for glutamate dehydrogenase, which deaminates L-glutamic acid, oxidases of natural amino acids are not very active in animal tissues. Therefore, most L-amino acids undergo indirect deamination by means of prior transamination, with the formation of glutamic acid, which then undergoes oxidative deamination or other transformations. Other types of deamination are reductive, hydrolytic (deamination of amino derivatives of purines, pyrimidines, and sugars), and intramolecular (histidine deamination), which occur mainly in microorganisms.


Zbarskii, B. I., I. I. Ivanov, and S. R. Mardashev. Biologicheskaia khimiia, 4th ed. Leningrad, 1965.
References in periodicals archive ?
formation of carbocations from the deamination of N-substituted
If the sample is not centrifuged and analyzed promptly, ammonia is formed by the continuous deamination of amino acids.
For assay of the RNA synthetic activity of GDH in the deamination and amination directions, the mini-whole gel elution fractions from a purification process were combined (total volume was ~11 mL, ~ 4 [micro]g protein per ml) and 0.
Nitrogen oxides, such as NO and its metabolite, peroxynitrite, are considered mutagenic because they can cause deamination of DNA and inactivation of DNA repair enzymes (Keefer and Wink, 1996; Tamir and Tannenbaum, 1996), and are predominant effectors in neurodegeneration (Chabrier et al.
Amine oxidase catalyses the oxidative deamination of amines to the corresponding aldehyde, ammonia, and hydrogen peroxide [8, 11]:
deamination, as found by Sen and Chalk (1993) who measured significant deamination following the application of urea to soil.
It is well documented that the enzyme phenylalanine ammonia-lyase (PAL), which catalyzes the deamination of phenylalanine to cinnamic acid (a key reaction in the biosynthesis of a wide range of secondary plant products such as phenolics, flavonoids, lignins, etc.
Skatole, one of the most malodorous compounds, can be produced during the process of deamination and decarboylation of tryptophan by bacterial strains of Bacteroidetes (Chung et al.
Recently, using high-resolution melting (HRM) screening and Sanger sequencing of selected regions from the AKT1 (v-akt murine thymoma viral oncogene homolog 1), [5] EGFR (epidermal growth factor receptor), KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and BRAF (v-raf murine sarcoma viral oncogene homolog B1) [5] genes, we showed that the majority of artifactual SNCs in FFPE DNA are transitional C:G > T:A changes resulting from cytosine deamination to uracil (12, 13).
They hypothesized this was a result of deamination, a process they say is "highly efficient if melamine is used as the sole nitrogen source.
DAO and /or PAO catalyze the oxidative deamination of amino groups of Put or Spd and Spm, respectively, producing the corresponding aldehyde, [H.