heart failure

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heart failure

1. a condition in which the heart is unable to pump an adequate amount of blood to the tissues, usually resulting in breathlessness, swollen ankles, etc.
2. sudden and permanent cessation of the heartbeat, resulting in death

Heart Failure


(cardiac insufficiency), a combination of disorders caused primarily by a reduction in cardiac contractility. Heart failure may occur if the heart is overstrained as a result of arterial hypertension or heart disease or if the blood supply to the heart is interrupted (myocardial infarction). Toxic influences, such as those produced during Graves’ disease, and myocarditis may also cause heart failure.

Heart failure is accompanied by congestion, because the weakened cardiac muscle cannot handle circulation. Left ventricular heart failure results in pulmonary congestion accompanied by dyspnea, cyanosis, and hemoptysis, whereas right ventricular heart failure results in passive congestion of systemic circulation marked by the development of edemas and the enlargement of the liver. Heart failure results in hypoxia of the organs and tissues, acidosis, and other metabolic disorders. Acute heart failure usually occurs in the left ventricle and is manifested by an attack of cardiac asthma.

Heart failure is treated with cardiac glycosides, diuretics, and antiarrhythmics. Surgery, for example, the implantation of a pacemaker, may be performed in certain cases.

heart failure

[′härt ‚fāl·yər]
References in periodicals archive ?
Cardioprotection-a new paradigm in the acute management of decompensated heart failure.
Implementation of NT-proBNP testing may result in significant reductions in hospital length of stay as well as improvements in rates of morbidity and mortality in patients with acute decompensated heart failure.
The half-life time of human BNP is ~20 min (8), and a previous study showed that BNP may be able to reflect changes in PCWP every 2 h during a tailored intravenous treatment (other than levosimendan) of decompensated heart failure (5).
CXL-1020, a proprietary nitroxyl donor, is Cardioxyl's lead compound for the intravenous treatment of acute decompensated heart failure (ADHF).
Different optimum values with different sensitivities, specificities, positive and negative predictive values, and overall accuracies will be observed in the diagnosis in acutely decompensated heart failure when compared with use of titrating treatment in established chronic heart failure (as in the current trial) or with population screening for asymptomatic ventricular impairment.
The Company also is planning to initiate a Phase 2 study of vepoloxamer in patients with acute decompensated heart failure in the first half of 2015.
Cardioxyl's lead program is focused on the development of proprietary nitroxyl donors for the treatment of acute decompensated heart failure (ADHF).
We believe that the results of this trial are immediately applicable to a large proportion of patients admitted with decompensated heart failure," said Dr.
4 Hyperuricemia is a Predictor of Prognosis in Patients with Acute Decompensated Heart Failure
We look forward to exploring the potential of MST-188 in this area of significant unmet medical need through a Phase 2 study in patients with acute decompensated heart failure, which we expect will begin recruiting patients in the first half of 2015.
Nesiritide was approved in 2001 for patients with acutely decompensated heart failure with dyspnea at rest or with minimal activity, but it has been used off label in chronic heart failure.