Follicular dendritic cell dedifferentiation
by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility.
By definition, cell dedifferentiation
is a reverse process in which the fully specialized cells return to their primitive cell forms-the stem cell.
The trick they have is dedifferentiation
of mature cells.
Taken together, EP inhibits myofibroblast expansion and cytoskeletal proteins expression, accompany by the capacity of release collagen secretion, suggest that EP may disturb the process of renal interstitial cells dedifferentiation
Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
It did not reappear until tumor transformation had occurred, a phenomenon that was termed "derepressive dedifferentiation
Gleason score, age and screening: modeling dedifferentiation
in prostate cancer.
The scientists initially noticed the high concentration of oncostatin M in tissue samples from the hearts of patients suffering from myocardial infarction, and it is already known that this protein is responsible for the dedifferentiation
of different cell types.
into a high-grade carcinoma, which is rare, heralds a poor prognosis (figure 3).
In parallel, a sort of dedifferentiation
program seems to operate in order to clean the cytoplasm from microgametogenesis-related molecules (reviewed in Maraschin et al.
The capacity of MSC self-maintenance has been reported (Bischoff, 1994) and it has been speculated that asymmetric division of MSCs, dedifferentiation
of myogenic cells and contribution from stem cells may be the mechanisms of self-renewal (Asakura et al.
In addition, tumor dedifferentiation
can lead to an absence of Tg synthesis or synthesis of Tg with altered biochemical features, obscuring recognition by the antibodies used in the Tg assay (22).