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dedifferentiation |
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dedifferentiation [dē‚dif·ə‚ren·chē′ā·shən] (biology) Disintegration of a specialized habit or adaptation. (cell and molecular biology) Loss of recognizable specializations that define a differentiated cell. (physiology) Return of a specialized cell or structure to a more general or primitive condition. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| The well-differentiated and myxoid types are associated with uniformly good outcomes, including lower recurrence rates (30 to 50%) and excellent survival (75 to 100% at 5 yr); also, these two types do not metastasize unless they undergo dedifferentiation to a high-grade liposarcoma, which is a rare, time-dependent process most often associated with incompletely treated and multiply recurrent liposarcomas. This dedifferentiation connects with a larger anxiety playing out across the show, also evident in a piece from another series, the epic, fifteen-part Soup Painting 2: Primordial Soup with Homoeopathic Dilutions, 2003-2004. By interfering with normal follicular dendritic cell function, age likely has the same effect on transmissible spongiform encephalopathies as has been observed due to dedifferentiation of follicular dendritic cells (8). |
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