dedifferentiation


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dedifferentiation

[dē‚dif·ə‚ren·chē′ā·shən]
(biology)
Disintegration of a specialized habit or adaptation.
(cell and molecular biology)
Loss of recognizable specializations that define a differentiated cell.
(physiology)
Return of a specialized cell or structure to a more general or primitive condition.
References in periodicals archive ?
Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility.
By definition, cell dedifferentiation is a reverse process in which the fully specialized cells return to their primitive cell forms-the stem cell.
The trick they have is dedifferentiation of mature cells.
Taken together, EP inhibits myofibroblast expansion and cytoskeletal proteins expression, accompany by the capacity of release collagen secretion, suggest that EP may disturb the process of renal interstitial cells dedifferentiation into myofibroblasts.
Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.
It did not reappear until tumor transformation had occurred, a phenomenon that was termed "derepressive dedifferentiation.
The scientists initially noticed the high concentration of oncostatin M in tissue samples from the hearts of patients suffering from myocardial infarction, and it is already known that this protein is responsible for the dedifferentiation of different cell types.
Dedifferentiation into a high-grade carcinoma, which is rare, heralds a poor prognosis (figure 3).
In parallel, a sort of dedifferentiation program seems to operate in order to clean the cytoplasm from microgametogenesis-related molecules (reviewed in Maraschin et al.
The capacity of MSC self-maintenance has been reported (Bischoff, 1994) and it has been speculated that asymmetric division of MSCs, dedifferentiation of myogenic cells and contribution from stem cells may be the mechanisms of self-renewal (Asakura et al.
In addition, tumor dedifferentiation can lead to an absence of Tg synthesis or synthesis of Tg with altered biochemical features, obscuring recognition by the antibodies used in the Tg assay (22).