demethylation


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demethylation

[de‚meth·ə′lā·shən]
(organic chemistry)
Removal of the methyl group from a compound.
References in periodicals archive ?
An experimental study has shown that cigarette smoke condensates can induce DNA demethylation in repeat elements such as LINE-1 and D4Z4 (Liu et al.
Specifically, the process of DNA demethylation, which is poorly characterised due to technological limitations.
It's been controversial that Gadd45b can promote epigenetic changes like global DNA demethylation, but we show that it can promote demethylation of certain genes," says Song.
Homocysteine (HCY) is a thiol-containing amino acid produced by the intracellular demethylation of the essential amino acid methionine.
Methylation silences or 'shuts off' genes that need to be turned off or are not functioning as they should, whereas the reverse process called demethylation 'turns on' healthy genes and genes needed at critical times in development," he added.
In May 2004, the FDA approved Vidaza, the first in a new class of drugs called demethylation agents, for treatment of all five subtypes of Myelodysplastic Syndromes (MDS).
Demethylation to 13-O-demethyltacrolimus by cytochrome P450 3A (CYP3A) [5] is quantitatively the most important metabolic route (6, 7,10,11).
The manipulation of these CpG islands through methylation or demethylation is instrumental in regulating gene expression for a number of processes in the brain, particularly the maintenance and consolidation of long-term memory.
Previous work from the host laboratory has revealed that disease-related genes are negatively regulated by DNA methylation and that DNA demethylation is required to enable proper plant innate immune response.
Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidineinduced demethylation of the hMLH1 gene promoter.