Over the past 10 years, the Medical Center Cologne has treated roughly 3,800 of patients with dendritic cell
therapy for conditions that included brain tumors, primary bone cancer and bone metastasis, breast cancer, colon cancer, liver metastasis of all kinds, cholangiocarcinomas, lung cancer, malignant melanoma, and prostate cancer.
The design of dendritic cell
cancer vaccine is likely to improve and much emphasis will be on multiple cancer antigen targeting capabilities of a single molecule.
Efficient targeting of protein antigen to the dendritic cell
receptor DEC-205 in the steady state leads to antigen Presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance.
Two ongoing clinical trials at BIIR are designed to test whether clinical response rates to dendritic cell
vaccines in patients with stage IV melanoma can be increased by pretreating patients with low-dose cyclophosphamide to eliminate or control naturally occurring suppressor T cells.
Follicular dendritic cell
tumor is morphologically characterized by a neoplastic proliferation of spindle to ovoid cells having histologic and immunohistochemical (IHC) features characteristic of follicular dendritic cells
In addition, Argos has used its dendritic cell
expertise to develop two novel treatments (one an antibody, the other a soluble protein) for autoimmune disorders and transplantation.
Extranodal follicular dendritic cell
tumor of the tonsil: Report of a diagnostic pitfall and literature review.
New research reveals that it may also affect the immune system by altering how dendritic cells
respond to biochemical signals [EHP 114:1083-1091; Goth et al.
Res]) are likely traosported from the gut to lymphoid tissue by cells such as migrating intestinal dendritic cells
Population Council immunologist Melissa Pope has studied dendritic cells
and HIV for more than a decade.
The extracted cells are known as dendritic cells
(DCs), a class of immune cells known to play a pivotal role in starting an immune response.
Akira Takashima, dermatology professor at University of Texas' Southwestern Medical Center in Dallas, focused on specialized dendritic cells
which regulate immune responses for antigens.