dephosphorylate


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dephosphorylate

[‚dē·fäs′fȯr·ə‚lāt]
(biochemistry)
To remove a phosphate group.
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IAP can dephosphorylate LPS on the outer membrane of gram-negative bacteria, thereby reducing its toxicity (Poelstra et al.
1] dephosphorylates PDGF receptors decreasing its activity as the growth factor (9).
PTEN contains an N-terminal phosphatase domain that can dephosphorylate phosphotyrosine, phosphoserine, and phosphothreonine within highly acidic substrates, although with weak catalytic activity.
This process activates calcineurin to dephosphorylate NFATc transcription factors.
However, the P component of phytate (282 g/kg) is only partially available to pigs because the endogenous phytase activity in the small intestinal mucosa is insufficient to effectively dephosphorylate phytate.
Several members can efficiently dephosphorylate p38[alpha] and p38[beta] (36-38); however, p38[gamma] and p38[delta] are resistant to all known MAPK phosphatase family members.
The reactions were carried out for 30 cycles at 96[degrees]C for 10 sec, 50[degrees]C for 5 sec and 60[degrees]C for 30 see in a PCR 9700 instrument (Applied Biosystems, Foster City, USA) and digested with Shrimp alkaline phosphatase to dephosphorylate unincorporated fluorescent ddNTPs.
Four isoforms of PDK (PDK1, PDK2, PDK3 and PDK4) phosphorylate specific serine residues on the [alpha]-subunit of E1 and two isoforms of PDP (PDP1 and PDP2) dephosphorylate the residues.
G2 arrest ensues due to the inability of Cdc25c to dephosphorylate inhibitory phosphorylation sites on Cdkl (Bartek and Lukas 2003).
Results from previous studies indicated that SPS is phosphorylated by Ser\Thr protein kinase and that this inhibits the activity of SPS in the dark, however SPS can dephosphorylate and recover activity by protein phosphatase 2 (PP2A) (Huber and Huber, 1996) under illumination, indicating that SPS can exercise certain abilities at high temperature.
DUSP1, also known as MALIK phosphatase 1 (MKP1), can dephosphorylate p38, which is considered to be an effective anti-inflammatory kinase that is controlled by GR.
Scientists have identified enzymes that acetylate, deacetylate, phosphorylate, dephosphorylate, and methylate histones.