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depurination

   Also found in: Wikipedia 0.01 sec.
depurination [dē‚pyu̇r·ə′nā·shən]
(biochemistry)
Detachment of guanine from sugar in a deoxyribonucleic acid molecule.


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85-93 DNA REPAIR PATHWAYS Errors in replication, extracellular influences such as UV light, radiation, and chemicals, and endogenous influences such as oxygen radicals routinely cause DNA damage, generally depurination, deamination, nonenzymatic methylation, and hydrolysis, sometimes with the attachment of a chemical group to DNA, the combination of which is termed an adduct.
2] can interact with DNA and, in turn, lead to depurination of DNA--a potential mutagenesis event (Cavalieri et al.
This depurination of the SR loop results in irreversible inhibition of protein synthesis at the translation step by impairing both the elongation factor (EF) 1-dependent binding of aminoacyl-tRNA and the GTP-dependent binding of EF-2 to the affected ribosome (Gessner and Irvin, 1980).
 
 
 
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