depurination


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depurination

[dē‚pyu̇r·ə′nā·shən]
(biochemistry)
Detachment of guanine from sugar in a deoxyribonucleic acid molecule.
References in periodicals archive ?
If the environment is more acidic (low pH), acid depurination is promoted, and if it's more alkaline, hydrolysis of the sugar-phosphate backbone increases.
Evidence that a burst of DNA depurination in SENCAR mouse skin induces error-prone repair and forms mutations in the H-ras gene.
Heating in the presence of a strong acid causes depurination (the release of the purine bases) and hydrolysis of the RNA strands to give free pyrimidine nucleotides, ribose, and phosphate.
Sodium adducts and depurination products in the spectrum were minor and did not interfere with assignment of genotype.
25 N HC1 for 10 minutes to allow partial depurination and cleavage of large fragments, in denaturation solution composed of 0.
2] can interact with DNA and, in turn, lead to depurination of DNA--a potential mutagenesis event (Cavalieri et al.