Gene deletion of EED, another component of PRC2 complex required for EZH2-mediated H3K27me3, has been reported to induce pancytopenia and increased apoptosis via derepression
of p16 and p19 tumor suppressors as well as several EZH2 target genes HoxC4, Id2, Sox7 and Noxa.
Microbial adaptation depends on many factors, such as the induction or derepression
of specific enzymes for degradation pathways or an adaptation of existing catabolic enzymes to the degradation of novel compounds.
07% for an epigenetics cell-based assay [Locus DeRepression
(LDR)] (Figure 1) to as much as 41% for a biochemical assay that evaluated the ability of compounds to interact with cytochrome P450 CYP1A2 (Figure 3).
Moreover, the strategy of silencing EMT inducers, such as Snail, with shRNAs has been shown to exert a double effect: it inhibits the epithelial-mesenchymal change and promotes the inverse mesenchymal-epithelial change via E-cadherin derepression
may be expected to result in derepression
of the REST/coREST complex and, consequently, inhibition of neuronal differentiation.
Extracellular proteome analysis also revealed derepression
of the Fur-regulated YoaJ protein, a predicted endoglucanase.
Cyclic AMP, which was applied toward protoplasts of Saccharomyces cerevisiae to eliminate the glucose effect, was not effective on the derepression
of the catalase induction in the intact cells of C.
of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.
Clinically relevant mutations that cause derepression
of the Neisseria gonorrhoeae mtrC-mtrD-mtrE efflux pump system confer different levels of antimicrobial resistance and in vivo fitness.
Pb stimulates delta-aminolevulinic acid synthetase (ALAS), through feedback derepression
, with a threshold in human leukocytes at a blood Pb of about 40 [micro]g/dl.
McKenney DJ, Drury CF, Wang SW (2001) Effects of oxygen on denitrification, repression, and derepression
in soil columns.
The Saccharomyces cerevisiae INO4 gene encodes a small, highly basic protein required for derepression
of phospholipid biosynthetic enzymes.