desmin


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Related to desmin: Titin, vimentin

desmin

[′dez·mən]
(biochemistry)
The muscle protein forming the Z lines in striated muscle.
References in periodicals archive ?
32,33) Immunostaining for muscle markers proves useful in these cases, but it should be remembered that desmin may only show focal positivity in leiomyosarcoma of the breast.
The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium: a novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, P-glycoprotein and Bcl-2.
The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium:a noveluse for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, P-glycoprotein and Bcl-2.
Finally, solitary fibrous tumors are immunoreactive for mesenchymal markers such as vimentin and negative for desmin, epithelial markers (cytokeratin), vascular markers (factor VIII-related antigen), and neural markers (S-100 protein).
In the osteoclastic giant cell leiomyosarcoma of kidney, you should have positive immunoreactivity with smooth muscle actin, desmin and pancytokeratin.
Immunostains for smooth muscle markers, including SMA, caldesmon, and desmin, are typically strong in leiomyoma and leiomyosarcoma, but obviously play no role in differentiating those 2 neoplasms.
Approximately 60% express CD 34; 35% to 55% express estrogen receptor/progesterone receptor (ER/PR) and 10% express desmin.
The palisaded histiocytes were positive for CD68, whereas smooth muscle actin (Figure 3) and desmin were positive in the necrotic area.
Clinical and demographic findings can help make distinctions, as can pertinent immunohistochemical reactions to synaptophysin, chromogranin, neuron-specific enolase (NSE), neurofilament protein (NFP), S-100 protein, keratin, CD45RB, desmin, CD99, and HMB45.
The tumour was uniformly negative for CD10, desmin and alpha-smooth muscle actin.
No immunoreactivity was observed for desmin, S100 protein, HMB-45, Mart 1, and Epstein-Barr virus (EBV) (data not shown).
Immunoprofiles of Similar Spindle Cell Neoplasms Tumor Type Myogenin Desmin SMA SC-RMS ++ ++ +/- Leiomyosarcoma - +/- ++ Low-grade myofibroblastic - +/- + sarcoma Fibrosarcoma - - +/- Malignant peripheral - - - nerve sheath tumor with rhabdomyoblastic differentiation Desmoplastic melanoma - - +/-- Tumor Type H-caldesmon S100 GFAP SC-RMS - - - Leiomyosarcoma +/- - +/-- Low-grade myofibroblastic - - - sarcoma Fibrosarcoma - - +/- Malignant peripheral - +/- - nerve sheath tumor with rhabdomyoblastic differentiation Desmoplastic melanoma - ++ +/- Abbreviations: GFAP, glial fibrillary acidic protein; SC-RMS, spindle cell rhabdomyosarcoma; SMA, smooth muscle actin; +, positive; ++, strongly positive; +/-, occasionally positive; +/--, occasionally positive, more often negative; -, negative.