desmoplasia


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Related to desmoplasia: dysplasia, adenocarcinoma, anaplasia, linitis plastica

desmoplasia

[‚dez·mə′plā·zhə]
(medicine)
The formation and proliferation of connective tissue, frequently in the growth of tumors.
The formation of adhesions.
References in periodicals archive ?
KEY WORDS: bisphenol A (BPA), desmoplasia, endocrine disruptor, hyperplastic ducts, mammary tumor, mast cells, N-nitroso-N-methylurea (NMU).
Desmoplasia involves the formation and proliferation of fibroblasts (cells that produce fibers and structural elements found in the extracellular matrix) and of fibrous connective tissue around the growing cancer.
The desmoplasia in malignant masses prevents tissue compression that would make the echoes uniform.
In addition, PDAC tumors often exhibit a high degree of desmoplasia, characterized by a fibrotic connective tissue stroma, the extent of which has been found to correlate with CTGF levels.
Extensive sampling of the whitish nodules from both lobes revealed tumor with exuberant desmoplasia and squamous differentiation similar to the biopsy without hepatocytic or any other line of differentiation (Figure 2).
2) The tumor can show a diverse morphology with cribriform, tubular, reticular, or solid architecture with prominent intratumoral infiltrate (usually neutrophils) and extensive desmoplasia.
Severe desmoplasia leads to stromal contamination and the extreme autodigestive properties often leads to degraded nucleic acids.
Tubulocystic carcinoma of the kidney is a well-circumscribed tumor with pure tubular and cystic growth patterns, cysts and tubules lined by a single layer of atypical cells with abundant eosinophilic cytoplasm and a variable hobnail appearance, and stromal desmoplasia (Figure 9).
Desmoplasia is frequently absent or poorly developed at this stage; if present, desmoplasia usually signifies submucosal invasion.
Third, some cancers, particularly mucinous or colloidal carcinomas may invade tissues with a broad, pushing growth pattern, so one need not see infiltrating glands or desmoplasia to make a diagnosis of malignancy.
Tumors with nodularity frequently also demonstrate desmoplasia as identified by diffuse pericellular reticulin, (16) however, not all cases with diffuse pericellular reticulin exhibit pale nodules.
13) Other findings include increased (>5 per high-power field) mitotic activity, comedonecrosis, micropapillary and squamoid growth patterns, and fibrocellular desmoplasia.