desmosome


Also found in: Dictionary, Medical, Wikipedia.

desmosome

[′dez·mə‚sōm]
(cell and molecular biology)
References in periodicals archive ?
He says there are exciting implications for these findings, "This is the first time that any structural information has been reported for desmosome adhesion.
In aged skin, desmosomes are down-regulated or prematurely degraded.
We know that people who have defects in their desmosomes have problems with their epidermis and get extremely unpleasant skin diseases.
In 2005, in a study published in Cell, Attardi first showed that Perp is integral to desmosomes.
Desmosomes attach neighbouring cells together and it is these tiny collections of proteins, which are responsible for the mechanical strength of organs and tissues within the body.
Trophoblast cells of sheep are united laterally by desmosomes and are low cuboidal until d 12, after which time they become columnar and more secretory by d 14.
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.
The disease affects desmosomes that constitute the gap junctions between myocytes.
GI mucosal barrier integrity is maintained by junctional complexes between epithelial cells including tight junctions, desmosomes and adherens junctions [36-38].
Examination of tumor cells on electron microscopy will reveal (1) desmosomes, (2) arrays of cytoplasmic, uniformly dispersed microfilaments in the presence or absence of dense bodies, and (3) pinocytotic vesicles with basal lamina separating the tumor cells from the stroma.
The cell membrane projects numerous microvilli into the canalicular lumen and desmosomes, and tight junctions assure the cohesion (Bruslé and Anadon, 1996).