This Note surveys the courts' approaches to other obviousness challenges in the chemical arts in an attempt to discern how they will address the deuteration of known compounds in an obviousness inquiry.
Although deuteration is a technique which may be utilized in any drug development program, recently small pharmaceutical companies have applied for patent protection covering deuterated analogs of FDA-approved drugs and drugs that are currently in clinical trials.
Creating this scattering length density contrast between the polystyrene and the BPP by selective deuteration allows for the determination of the relative position versus the thickness of each component within the film.
These observations illustrate the excellent sensitivity of selective deuteration in neutron reflectivity.
Auspex Pharmaceuticals, a developer of next-generation medicines through the targeted deuteration
of clinically validated drugs, today announced three key management hires.
In this work, selective deuteration
of the methyl groups of the quaternary nitrogen enabled the orientation of this group to be determined.
1] (Fluka Chemica, deuteration
degree not less than 99.
Auspex Pharmaceuticals, a clinical stage company developing next-generation medicines with improved safety and performance through the targeted deuteration
of clinically validated drugs, today announced the appointment of Michael Grey as President and Chief Executive Officer and R.
Bates and Wignall (21) investigated the effect of deuteration
of one component on X in a polymer blend by SANS.
Auspex Pharmaceuticals, a developer of next-generation medicines with improved safety and performance through the targeted deuteration
of clinically validated drugs, today announced positive results from its Phase 1 clinical trial evaluating SD-254, a Selective Serotinin-Norepinephrine Reuptake Inhibitor (SNRI).
Auspex was founded in 2001 and is the first company to apply targeted deuteration
to existing drugs and clinically validated drug candidates as a means of improving their safety and performance as therapeutics," said Pratik Shah.
BOC's proprietary gas-blending process allows precise, flexible, and real-time control of deuterium mixing for use in multiple deuteration