diacylglycerol


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Related to diacylglycerol: Protein kinase C, triacylglycerol

diacylglycerol

[‚dī·ə·səl′glis·ə‚rōl]
(biochemistry)
A product of the cleavage of membrane-associated phospholipid by phospholipase C that activates isozymes of protein kinase C, an important regulator of cell function.
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Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight.
In the current study, ATGL, LPL, and HSL activities of shrimp at both 3 and 30 were more than those at 17, indicating that lipid mobilization has increased, because ATGL (TAG hydrolysis), LPL, and HSL are crucial enzymes in lipid mobilization by performing the first step in hydrolyzing TAG to generate diacylglycerol and free fatty acid (Osuga et al.
Thus, for instance, FFA increase leads to the increment of certain intracellular metabolites, like diacylglycerol, Acil-CoA, and ceramides, which can activate Ser/Tre kinases (protein-kinase C[theta] that phosphorilate IRS 1 and 2 in Ser/Tre sites--reducing the receptor's ability to initiate the PI3k pathway and, thus, the decrease of glucose transport (32); TNF[alfa] can induce the activation of ceramide production, which can activate PKC [zeta] and with such IKK[beta]; the activity of the kinase c-Jun amino terminal (JNK1) has been related to FFA, the TNF-[alfa] that phosphorilates IRS-1 in the Ser307, decoupling the IR (33); in addition to other metabolic stress factors, like free radicals, hyperglycemia and hyperlipidemia (34).
Fat utilization in healthy subjects consuming diacylglycerol oil diet: dietary and whole body fat oxidation.
The binding of Ang II to AT1R can activate the phospholipase C on the cell membrane resulting in the hydrolysis of phosphatidylinositol phosphate and production of diacylglycerol.
Diacylglycerol oils: nutritional aspects and applications in foods.
Among the topics are the functional attributes that fats bring to food, health aspects of saturated fatty acids, nutritional characteristics of palm oil, nutritional aspects of diacylglycerol oils and applications in foods, reducing saturated fat in butchered meat and processed meat products, altering animal diet to reduce saturated fat in meat and milk, savory snacks and fried foods, biscuits, pastry, ice cream, and sauces.
This reduced transport is caused by lipid overload in the form of the accumulation of long-chain acyl-CoA (LCCoA) and diacylglycerol (DAG) inside the skeletal muscle cell.
2+] from intracellular stores, and diacylglycerol facilitates the activation of PKC.
acetylcholine, glutamate, and GABA) to natural activators such as diacylglycerol (DAG), phosphatidylserine (PS), arachidonic acid, and calcium, to PKC isozymes and then, to downstream substrates such as the mRNA stabilizing proteins (Hud, HuR), and, thereafter, to the synaptogenic proteins such as GAP43, BDNF, NGF, IGF, etc.
A bee insulin-immunoreactive peptide promptly lowered trehalose, glucose, diacylglycerol and phospholipid concentrations, and increased the levels of fatty acid and triacylglycerol.
Five of these loci [glucokinase (hexokinase 4) (GCK); diacylglycerol kinase, beta 90kDa-transmembrane protein 195 (DGKB-TMEM195); glucokinase (hexokinase 4) regulator (GCKR); ADCY5; PROX1] were also associated with T2D risk when tested in 40 655 diabetic cases and 87 022 controls (Table 2).