dibucaine


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dibucaine

[′dī·byə‚kān]
(organic chemistry)
C20H29O2N3 A local anesthetic used both as the base and the hydrochloride salt.
References in periodicals archive ?
The dibucaine and sil-1 mutations were analyzed by DNA sequencing because their relative proximity enabled them to be coamplified in a single 570-bp product.
In the 52 patients with hereditary hypocholinesterasemia, the most common DNA abnormalities were dibucaine and K-variant mutations: 47 patients carried the dibucaine mutation, whereas 48 were identified with the K-variant (allele frequencies, 0.
No homozygotes with fluoride or silent mutations were found, and none of the patients had an isolated homozygous dibucaine defect.
In total, 73% of patients with primary hypocholinesterasemia had abnormalities at the dibucaine and K-variant loci only.
This proband was heterozygous for dibucaine and K-variant, hence, compound heterozygous for three mutations (Fig.
Three patients had hypocholinesterasemia with BCHE gene defects: two K-variant homozygotes (patients 6 and 21), and one dibucaine heterozygote (patient 4; shown in the Data Supplement).
The importance of the dibucaine mutation in patients with primary hypocholinesterasemia was undisputable.