dichloroacetic acid


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dichloroacetic acid

[dī¦klȯr·ō·ə¦sēd·ik ′as·əd]
(organic chemistry)
CHCl2COOH A strong liquid acid, formed by chlorinating acetic acid; used in organic synthesis.
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Dichloroacetic acid (DCA) and trichloroacetic acid (TCA), the HAA5s most commonly found, are also of concern.
Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)-glutathione and S-(1,2-dicMorovinyl)-L-cysteine.
Conversion of trichloroacetic acid to dichloroacetic acid in biological samples.
Hepatocarcinogenicity in the male B6C3F1 mouse following a lifetime exposure to dichloroacetic acid in the drinking water: dose-response determination and modes of action.
Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid.
The TCE metabolites TCA and dichloroacetic acid (DCA) bind to plasma proteins.
A quantitative description of suicide inhibition of dichloroacetic acid in rats and mice.
For liver toxicity and/or carcinogenesis, the TCE metabolites dichloroacetic acid (DCA) and trichloroacetic acid (TCA), both of which induce liver tumors in rodent laboratory studies, have been the major focus of study as potential active agent(s).
Growth retardation has also been reported in mice exposed to dichloroacetic acid (Smith et al.
Key words: animal study, dichloroacetic acid, drinking water disinfection by-products, halogenated acetic acids, human risk assessment, human in vitro metabolism, low-dose pharmacokinetics, oral bioavailability, rat in vitro metabolism, toxicology.

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