The clinical benefits of didanosine
for certain patients with HIV continue to outweigh its potential risks," but the decision to prescribe the drug "must be made on an individual basis between the treating physician and the patient," the FDA said.
The patients had been taking didanosine
for months to years before developing noncirrhotic portal hypertension, and "definitive cases .
The FDA approves Bristol-Myers Squibb's enteric-coated didanosine
(Videx EC) capsules.
In addition, after changes in therapy for hyperlactatemic patients (mainly interruption of stavudine and/or didanosine
, identified as risk factors for hyperlactatemia), the proportion of patients with a lactate [greater than or equal to]2.
, sold by Bristol-Myers Squibb under the brand name Videx, costs approximately $2.
3]; at that time, HAART was changed to include ritonavir, indinavir, stavudine, and didanosine
The agents in this class include: zidovudine (Retrovir[R]), didanosine
(Videx[R]), zalcitabine (Hivid[R]), stavudine (Zerit[R]), lamivudine (Epivir[R]), lamivudine/ zidovudine (Combivir[R]), and the newest NRTI, abacavir (Ziagen[R]).
Concomitant antiretroviral agents used with NVP for PEP included zidovudine and lamivudine ; stavudine and lamivudine (three); zidovudine and didanosine
(two); stavudine and didanosine
(one); stavudine and indinavir (one); didanosine
and indinavir (one); stavudine, didanosine
, and ritonavir (one); lamivudine, didanosine
, and nelfinavir (one); stavudine, lamivudine, nelfinavir, and saquinavir (one); and none (one).
The GPO also successfully manufactured didanosine
, better known as ddI, in March.
Those taking the drugs hydroxyurea and didanosine
may be especially likely to respond well, she says.
(ddI, Dideoxyinosine, Videx), Bristol Myers-Squibb
(ddI), for example, recently approved by the US Food and Drug Administration as the second commercially available anti-HIV drug, is mentioned only briefly as an experimental therapy.