pointed out that the recent approval of dideoxyinosine
(DDI) -- the second drug that has been found to be effective against AIDS -- was made possible by the application of several innovative concepts recommended by the working group.
8%) without inducing drug resistance, significantly increased CD4+ T cells by up to 135 cells/mm3in the dideoxyinosine
200 mg/hydroxycarbamide 900 mg cohort (doses lower than traditionally investigated), while also rapidly and significantly reducing markers of excessive immune activation.
Agent Effective Ineffective Interferon Interferon-[alpha] Interferon-[gamma] Antiviral Acyclovir Dideoxyinosine
Azudothymidine Foscarnet Immunomodulatory Prednisone Interleukin-2 Thymosin Levamisole Agent Toxic Under evaluation Interferon Interferon [beta] Antiviral Fialuridine Ribavirin Adenine Lamivudine Arabinoside Immunomodulatory Adoptive immune transfer Modified from Lok ASF.