Another method used naltrexone, and still another used digitoxin
Anti-digoxin Fab fragments have been suggested and used as antidotes in intoxications caused by other digitalis-like molecules such as oleandrin (7-9), bufadienolide-containing aphrodisiacs (10), digitoxin
(11), and foxglove extract (12); they have also been successfully used to reverse hypertension believed linked to increased digoxin-like immunoreactive factors in blood (13).
Cardiac drugs for which commercial automated immunoassays are available on various platforms for use in clinical laboratories (ranging from small physicians' offices to large referral laboratories) include digoxin, procainamide and N-acetylprocainamide (NAPA), quinidine, lidocaine, disopyramide, flecainide, and digitoxin.
in European countries digitoxin (Crystodigin) is also used for similar indications.
Because these effects resemble the clinical condition for which the drug is administered (82), it is recommended that the serum concentration of digoxin or digitoxin be monitored to determine if the drug dose needs to be increased (if the patient is subtherapeutic) or if a possible overdose needs to be treated (if the serum concentration of the drug is above the therapeutic range).
We have observed significant analytical discrepancies (20% to 220%) in digitoxin (Crystodigin; DTN) immunoassay results for 11 serum samples from patients taking digitoxin.
Initially, we expected the deglycosylated congeners of digitoxin (i.
Digoxin and digitoxin display marked differences in antibody binding, despite being practically identical (digitoxin lacks a hydroxyl group at C-12 on the steroid backbone).
3 Digitoxin 78 Ouabagenin 55 Strophanthidin 47 Dihydroouabain 0.
Digitoxin was measured in one laboratory by using a FPIA on the TDx analyzer (Abbott Diagnostics).
The therapeutic range of digitoxin is a10-fold that of digoxin.
E--acetyldigoxin, cyclosporine, digitoxin
, digoxin, levothyroxine, and potassium iodide only fixed combinations , phenytoin.