Flaxseed is a rich source of the polyunsaturated fat alpha-linolenic acid and the richest-known dietary source of lignans (phytoestrogens), particularly secoisolariciresinol diglucoside
Potential protective properties of flax lignan secoisolariciresinol diglucoside
Background: The cyanogenic diglucoside
, amygdalin, has gained high popularity among cancer patients together with, or in place of, conventional therapy.
In addition, this fraction contained quercetin, glucosylated derivatives of quercetin and quercetagetin, and diglucoside
of quercetagetin with protonated molecules at m/z 303,465, 481, and 643, respectively.
32 Peonidin-3,5-O- diglucoside
-- -- Malvidin-3,5-O- diglucoside
-- -- Malvidin-3-O-glucoside 46.
Gurbuz I, Yesilada E, Ito S (2009) An anti-ulcerogenic flavonol diglucoside
from Equisetum palustre L.
Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside
isolated from flaxseed.
While the condition for phytoestrogen activity in the case of lignans is completely dependent on colonic bacteria that convert the precursor, secoisolariciresinol diglucoside
into enterodiol and enterolactone (Aldercreutz 1998), isoflavones are inherently estrogenic and may become further activated by conversion to equol, a bacterial metabolite of daidzein in the gastrointestinal tract (Setchell 2002).
B) those that contain tetracyclic triterpenes, such as cucurbitacin R diglucoside
, which structurally resemble the specific corticosteroids that inactivate the stress system to protect against overreaction to stressors.
Suppression of phosphoenolpyruvate carboxykinase gene expression by secoisolariciresinol diglucoside
(SDG), a new antidiabetic agent.
Hendrich developed the study with ISU master's student Kai Ling Kong and doctoral graduates Zhong Ye, Xianai Wu, and Sun-Ok Lee to determine whether the main lignan in flaxseed, secoisolariciresinol diglucoside
, could lower cholesterol.
Quantitation of the lignan secoisolariciresinol diglucoside
in baked goods containing flax seed or flax meal.