CONCLUSIONS: Current asthma was associated with the highest quartiles of MCOP and MCNP, metabolites of two high molecular weight phthalates, diisononyl phthalate and diisodecyl phthalate
BACKGROUND: High-molecular-weight phthalates, such as diisononyl phthalate (DINP) and diisodecyl phthalate
(DIDP), are used primarily as polyvinyl chloride plasticizers.
The following 11 phthalate metabolites were measured at the CDC (Atlanta, GA, USA): mono(2-ethylhexyl) phthalate (MEHP), monobenzyl phthalate (MBzP), MBP, MEP, mono-isobutyl phthalate (MiBP), three oxidized metabolites of DEHP [mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-ox-ohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP)], mono(3-carboxypropyl) phthalate [MCPP; an oxidized metabolite of both DBP and di-n-octyl phthalate (DOP)], and monocarboxyisooctyl phthalate (MCOP) and monocarboxyisononyl phthalate (MCNP) (oxidized metabolites of diisononyl phthalate and diisodecyl phthalate
Also, the European Parliament voted in 2005 to ban the use of three phthalate plasticizers (DEHP, di-n-butyl phthalate, and benzyt butyl phthalate) in toys and child care items, and to prohibit the use of three others (diisononyl phthalate, diisodecyl phthalate
, and di-n-octyl phthalate) in toys and child care items that children can put in their mouths.
NTP-CERHR Expert Panel Report on Diisodecyl Phthalate
Jayflex phthalate plasticizers include dihexyl phthalate (DHP), diisoheptyl phthalate, diisononyl phthalate (DINP), diisodecyl phthalate
(DIDP), undecyl dodecylphthalate (UDP), and ditridecyl phthalate (DTDP).