DNA-strand breaks induced by dimethylarsinic acid
, a metabolite of inorganic arsenics, are strongly enhanced by superoxide anion radicals.
Identification and quantification by LC-MS and LC-ICP-MS of arsenic species in urine of rats chronically exposed to dimethylarsinic acid
Minor amounts of monomethylarsonic acid (MMA), dimethylarsinic acid
(DMA), and methylated arsenic (III) species can also be present in natural waters.
The urinary excretion of arsenic metabolites after a single oral administration of dimethylarsinic acid
Speciation measurements by HPLC-HGAAS of dimethylarsinic acid
and arsenobetaine in three candidate lyophilized urine reference materials.
Rice grown in the United States has been shown to contain higher amounts of total arsenic and a lower proportion of inorganic arsenic [and higher organic arsenic in the form of dimethylarsinic acid
(DMA)] than rice from other countries (Meharg et al.
Gene damage induced in human alveolar type II (L-132) cells by exposure to dimethylarsinic acid
The 50% lethal doses for oral administration to mice are as follows: 3 mg/kg for arsine; 14 mg/kg for arsenite [As(Ill)]; 20 mg/kg for arsenate [As(V)]; 700-1800 mg/kg for monomethylarsonic acid (MMA), (4) 700-2600 mg/kg for dimethylarsinic acid
(DMA); and >10 000 mg/kg for arsenobetaine and arsenocholine (1).
One finding was that uCr was the strongest predictor of As methylation; participants with higher uCr concentrations had a higher percentage of total urinary As as dimethylarsinic acid
(DMA) compared to those with lower uCr.
As species calibrators of monomethylarsonic acid (MMA), dimethylarsinic acid
(DMA), and arsenobetaine (AsB) were provided by the Commission of the European Union, DGXII, Measurements and Testing Programme.
2011), we cited their earlier results concerning urinary dimethylarsinic acid
(DMA) and creatinine concentrations, noting that in 2005 they reported a strong correlation between urinary creatinine and the percentage of DMA (DMA%) (Gamble et al.
The main As species in the serum of these patients are dimethylarsinic acid
(DMA) and arsenobetaine (AsB), respectively carrying 15.