combination relates to the US65415Q9 (2003) chemotherapy for synergistic effects the treatment of of Taxol cancer in combination with discodermolide
in treatment of cancer.
Thanks to the scientists chemical tool, researchers can now artificially produce this substance, called discodermolide
An example of such a compound is discodermolide
, a potential cancer drug extracted from a deep-water sponge.
Natural products effective against certain cancers have been identified: bryostatin from the colonial bryozoan, ecteinascidin from ascidians or sea squirts, and discodermolide
from deep-sea sponges.
The grant was awarded to Kosan to develop an efficient means of producing the polyketide discodermolide, a potential anti-cancer agent.
Discodermolide has been shown by researchers to inhibit cancer cells by the same mechanism as paclitaxel (the active ingredient in Taxol(R)), but also is effective against paclitaxel-resistant tumors.
Kosan has two other preclinical programs, a discodermolide
analog program focused on cancer and a ketolide program focused on anti-infectives.
These statements are subject to risks and uncertainties, including, without limitation, whether Kosan's discodermolide
research and development activities will lead to commercially valuable applications, Kosan's ability to maintain or establish collaborations and proprietary rights and avoid claims of infringement of third party proprietary rights and the risk factors included in Kosan's filings with the Securities and Exchange Commission, including its Annual Report on Form 10-K and other periodic reports it files with the SEC.
He has extensive experience with polyketides of interest to Kosan, including erythromycin, epothilone and discodermolide
Kosan currently is evaluating discodermolide analogs in preclinical studies with the goal of initiating clinical development in 2005.
The goal of this work is to use Kosan's genetic engineering technology to gain access to complex polyketide fragments and then assemble them using a short chemical sequence to make discodermolide analogs," said David C.
The report describes various natural sources of spindle poisons, including colchicine, curacin, combretastatins, cryptophycins, discodermolide
, dolastatin, auristatin PHE, symplostatin 1, epothilones, eleutherobin, halichondrin B, halimide, hemiasterlins, laulimalide, maytansinoids, PC-SPES, peloruside A, resveratrol, S-allylmercaptocysteine (SAMC), spongistatins, taxanes, Vinca alkaloids, vitilevuamide, etc.