disulfide bond


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disulfide bond

[dī¦səl‚fīd ′bänd]
(organic chemistry)
References in periodicals archive ?
The formation of cysteine-homocysteine disulfides has been suggested to disrupt the intramolecular disulfide bonds in fibrillin-1 (7).
After dissolving apoprotein in 200 [micro]L of 50 mmol/L NaOH at 60[degrees]C for 30 min, we reduced disulfide bonds by incubation with 20 [micro]L of 100 mL/L tri-n-butylphosphine in N,N-dymethilphormamide for 10 min, added 900 [micro]L of acetonitrile, vortex-mixed and centrifuged the solution at 2000g for 5 min, and then dried 1 mL of supernatant under decreased pressure at 60[degrees]C for 4 h.
We reduced the disulfide bond between the this and apoB-100 by adding TBP to the apoprotein solution.
As disulfide bonds photodegrade, hair experiences a loss in cystine content and a corresponding increase in cysteic acid.
He included one cysteine in each half of the molecule, and in his most advanced structure he has those amino acids attach to each other in a disulfide bond, thus holding together the two sheetlike sections.
The rate-determining step of the reaction is the attack of the phosphine nucleophile on the disulfide bond (15).
cellular import of disulfide-Hcy or intracellular reduction of the disulfide bond.
5%) is a first-in-class new chemical entity that targets a biochemical cause of presbyopia, believed to be associated with an increase in the formation of disulfide bonds between the crystalline proteins within lens fiber cells.
We aim to detect motion within the receptor on the angstrom scale by trapping conformational states during activation with artificial metal ion binding sites and disulfide bonds.
The tertiary structure of a protein is the three-dimensional structure and is stabilized by the series of hydrophobic amino acid residues and by disulfide bonds formed among two cysteine amino acid.
PolyTherics has developed ThioBridge(TM) for site-specific conjugation of cytotoxic payloads to disulfide bonds in proteins and antibodies to provide more stable and less heterogeneous drug conjugates.
They are based on alkaline reducing agents that swell the hair and break the disulfide bonds.