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disulfiram

   Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson 0.01 sec.
disulfiram [di′səl·fə‚ram]
(pharmacology)
C10H20N2S4A drug used to treat alcohol abuse that blocks the metabolism of acetaldehyde, the major metabolite of ethanol, causing a rapid buildup of acetaldehyde and a severe physiological syndrome intended to prevent or modify further immediate drinking behavior. Also known as Antabuse.


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Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
An index for assessing blindness in a multi-centre clinical trial: disulfiram for alcohol cessation--a VA cooperative study.
Important interactions between Kaletra and other agents, including rifabutin (Mycobutin), disulfiram (Antabuse), metronidazole (Flagyl), methadone (Dolophine) and corticosteroids, may require adjusted dosing of either drug and are noted in Kaletra's package insert.
 
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