dolichol


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dolichol

[′däl·ə‚kȯl]
(biochemistry)
Any of a group of long-chain unsaturated isoprenoid alcohols containing up to 84 carbon atoms; found free or phosphorylated in membranes of the endoplasmic reticulum and Golgi apparatus.
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The oligosaccharide was released from dolichol pyrophosphate by mild acid hydrolysis, studied by [sup.
2011), demonstrates to be the key point to reduce cholesterol and several compounds like isopentenyladenine, dolichol, ubiquinone, geranilpirofosfato (GGPP), farnesylpyrophosphate (FPP) (Wong et al.
In mammalian cells, the limiting substrate for dolichol biosynthesis is geranyl-geraniol (GGOH) of mevalonate pathway.
Branch point regulation is an important mechanism controlling carbon flow in the MVAP; the FPP produced by the MVAP can be shunted to many metabolic branches for the synthesis of critical molecules such as ubiquinone, dolichol, or prenylated proteins [59].
Guan believes dolichol profiling could effectively distinguish RP caused by DHDDS mutation from that caused by other mutations.
Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins.
The alteration in cell function resulting from the inevitable inhibition of CoQ10 and dolichol is giving us the rest of our broad list of incapacitating adverse effects--the rhabdomyolysis (breakdown of muscle fibers), permanent myopathy (dysfunction of muscle fibers), permanent neuropathy (damage to peripheral nerves) and ALS-like neuromuscular degeneration that has placed many hundreds in wheelchairs--yours truly included.
It metabolises to dolichol which participates in the glycosylation of proteins in membranes and in the formation of glycoproteins.
The isoprenoid metabolites (digoxin, dolichol, and ubiquinone), glycoconjugate metabolism, free radical metabolism, and the RBC membrane composition were studied.
Gamma-glutamyltransferase, aspartate and alanine aminotransferases and their ratio, mean cell volume and urinary dolichol in pregnant alcohol abusers.
Lipid peroxidation of microsomal and mitochondrial membranes extracted with n-pentane and reconstituted with ubiquinol, dolichol and cholesterol.