Dopa


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.
Related to Dopa: dopamine, DOPA decarboxylase

dopa

[′dō·pə]
(biochemistry)

Dopa

 

3,4-dihydroxyphenylalanine, C6H3(OH)2CH2CH(NH2)COOH, an amino acid.

In animals, dopa is one of the precursors in the chain of catecholamine biosynthesis. It is produced in tissues by the oxidation of tyrosine. In animals, plants, and some microorganisms, dopa is the first intermediate product in the synthesis of melanins. Healthy persons excrete from 50 to 55 μg of dopa daily with the urine; the amount increases in the presence of a neuroblastoma, a kind of malignant tumor. An inhibitor of dopa decarboxylase, a-methyldopa (Aldomet), is used in the treatment of parkinsonism and hypertension.

REFERENCES

Matlina, E. Sh., and V. V. Men’shikov. Klinicheskaia biokhimiia katekholaminov. Moscow, 1967.
Grollman, A. Klinicheskaia endokrinologiia i ee fiziologicheskie osnovy. Moscow, 1969. (Translated from English.)
References in periodicals archive ?
The optimal levels of the process variables for L- dopa formation in an aerobic biochemical reaction were the time of biochemical reaction, L-tyrosine concentration (2.
californica, analysis of the amino acid composition of the cement revealed that adhesive proteins are subjected to post-translational modifications, including hydroxylation of tyrosine residues into DOPA and phosphorylation of the serine residues (Waite et al.
Severe neuronal loss and 1987 gliosis in GP, rest of brain appears normal Decreased DA and DOPAC in putamen but not changed in the caudate HVA levels normal in most animals Decreased dopa decarboxylase activity in putamen of two-thirds of the animals ChAT activity reduced in GP of all animals GAD activity unaffected Glutathione levels decreased in the striatum, GP, and SN of one third of the animals Newland et al.
Cardiac transmitter stores were depleted, leading to a reduced contribution of "leakage" to transmitter turnover and a reduced requirement for activation of tyrosine hydroxylase, as assessed from measurements of cardiac spillover of DOPA.
the neurotransmitters DOPA and GABA, as well as hydrogen peroxide and vanadate also induce larval metamorphosis.
DOPA results when an enzyme adds a second hydroxyl group to the amino acid tyrosine.
One solution is a simple synthetic polymer containing DOPA, a key amino acid found in the sophisticated proteins that are essential to mussels' ability to adhere to wet surfaces, and the other is a catalyst.
In the present study, we therefore developed a human pharmacological model by which dopa can be measured as its free serum concentration after i.
Tenders are invited for Supply of L Alanine 1x25gm ,L Arginine 1x25gm ,L Asparagine monohydrate 1x25gm , LTH/Q/ 523 /Micro dated , L Cysteine monohydrate 1x25gm , L Dopa 3X5 gm ,L Phenyl Alanine 2x25gm , L Rhamnose monohydrate 1x5gm ,Light green 2x10gm ,M Inositol 2x25gm ,Magnesium chloride hexahydrate
Simple automated high-performance liquid chromatographic column-switching technique for the measurement of DOPA and 3-O-methyldopa in plasma.