dosage compensation


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dosage compensation

[′dō·sij ‚käm·pən‚sā·shən]
(genetics)
A mechanism that equalizes the expression in males and females of genes located on the X chromosome, despite their presence in two doses in the homogametic sex and a single dose in the heterogametic sex.
A mechanism that equalizes the expression of X-linked and autosomal genes by doubling the expression level of X-linked genes in male Drosophila and in both male and female mammals with their single active X.
References in periodicals archive ?
If the complex interacts with MSL instead, it binds to genes on the males' X-chromosome, playing its role in dosage compensation.
Strict dosage compensation of all genes on the chromosome isn't necessary," concludes study coauthor Laura Carrel.
Thus, the interaction between male-killer and host is not associated with somatic sex, so the target of detection and virulence is either before Sxl is produced, Sxl itself, or the dosage compensation or germ-line determination pathways.