Disposition

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disposition

Philosophy Logic a property that consists not in the present state of an object, but in its propensity to change in a certain way under certain conditions, as brittleness which consists in the propensity to break when struck

Disposition

 

(1) In the navy, the plan for placement of ships in the roadstead, at the base, and at anchor on the open sea. The disposition is drawn up in such a way as to make it convenient for individual units and the fleet as a whole to put out to sea.

(2) In the ground forces of the 18th and 19th centuries, a written order from the commander in which battle missions were given to subordinate units. In the Russian army the term “battle order” has been used in place of “disposition”in the 20th century.


Disposition

 

in civil law, one of the legal rights of the owner of any property. The right of disposition is exercised primarily by the carrying out of various transactions, such as buying and selling, exchange, or giving as a gift. Possession, use, and disposition together make up the right of ownership.

disposition

[‚dis·pə′zish·ən]
(computer science)
The status of a file after it has been closed by a computer program, for example, retained or deleted.
References in periodicals archive ?
Abbreviations: AUC, area under the time-plasma concentration curve; BCS, biopharmaceutical classification system; BDDCS, biopharmaceutics drug disposition classification system; CYP, cytochrome P450; GTE, green tea extract; EGCG, C-)-epigallocatechi n-3-gal late; OATP, organic anion transporting polypeptide; P-gp, P-glycoprotein.
Although pharmacogenomics continues to be the focus of discussions about personalized medicine, it is important to remember that nongenetic factors play a large role in drug disposition as well.
The technological applications of pharmacogenetics, including genotyping, drug disposition (metabolism and enzymes), and the impact of this research on the pharmaceutical industry and regulatory matters are all addressed in chapters by internationally recognized leaders from both academia and industry.
Along with improving the quality and accuracy of clinical data based on drug disposition, the transatlantic alliance aims to support early proof of concept studies and to assist drug innovators with more assured translation.
Drug disposition and pharmacokinetics; from principles to applications.
Single polymorphisms alone do not adequately predict drug disposition because multiple routes of metabolism or transport may compensate for deficiencies in a single pathway (3).
Among their topics are coordinating uptake and efflux transporters in drug disposition, predicting the intestinal solubility of poorly soluble drugs, and using computer reasoning about qualitative and quantitative information to predict metabolism and toxicity.
First published in 1976, Clinical Pharmacokinetics is the major clinical review journal in the area of pharmacokinetics, the study of drug disposition in the body that is an integral part of drug development and rational use.
The acquisition will significantly strengthen Simcyp's ability to relate molecular structure to drug disposition through collaborative links with Tripos and extend Simcyp's reach into clinical trial simulation, IVIVC and PK/PD modelling and simulation through collaborative links with Pharsight.

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