Abbreviations: AUC, area under the time-plasma concentration curve; BCS, biopharmaceutical classification system; BDDCS, biopharmaceutics drug disposition
classification system; CYP, cytochrome P450; GTE, green tea extract; EGCG, C-)-epigallocatechi n-3-gal late; OATP, organic anion transporting polypeptide; P-gp, P-glycoprotein.
Although pharmacogenomics continues to be the focus of discussions about personalized medicine, it is important to remember that nongenetic factors play a large role in drug disposition
Principles of drug transfer into breast milk and drug disposition
in the nursing infant.
The technological applications of pharmacogenetics, including genotyping, drug disposition
(metabolism and enzymes), and the impact of this research on the pharmaceutical industry and regulatory matters are all addressed in chapters by internationally recognized leaders from both academia and industry.
Along with improving the quality and accuracy of clinical data based on drug disposition
, the transatlantic alliance aims to support early proof of concept studies and to assist drug innovators with more assured translation.
and pharmacokinetics; from principles to applications.
Single polymorphisms alone do not adequately predict drug disposition
because multiple routes of metabolism or transport may compensate for deficiencies in a single pathway (3).
Among their topics are coordinating uptake and efflux transporters in drug disposition
, predicting the intestinal solubility of poorly soluble drugs, and using computer reasoning about qualitative and quantitative information to predict metabolism and toxicity.
First published in 1976, Clinical Pharmacokinetics is the major clinical review journal in the area of pharmacokinetics, the study of drug disposition
in the body that is an integral part of drug development and rational use.
The acquisition will significantly strengthen Simcyp's ability to relate molecular structure to drug disposition
through collaborative links with Tripos and extend Simcyp's reach into clinical trial simulation, IVIVC and PK/PD modelling and simulation through collaborative links with Pharsight.